Progress in biomedical technology (cochlear, vestibular, and retinal implants) has led to
remarkable success in neurosensory restoration, particularly in the auditory system …

Age-related hearing loss (ARHL) is a common, increasing problem for older adults, affecting
about 1 billion people by 2050. We aim to correlate the different reductions of hearing from …

The noise-induced and age-related loss of synaptic connections between auditory-nerve
fibers and cochlear hair cells is well-established from histopathology in several mammalian …

Functional molecular characterization of the cochlea has mainly been driven by the
deciphering of the genetic architecture of sensorineural deafness. As a result, the search for …

Sound stimulus is encoded in mice by three molecularly and physiologically diverse
subtypes of sensory neurons, called Ia, Ib, and Ic spiral ganglion neurons (SGNs). Here, we …

Mature mammalian cochlear hair cells (HCs) do not spontaneously regenerate once lost,
leading to life-long hearing deficits. Attempts to induce HC regeneration in adult mammals …

Macrophages are recruited into the cochlea in response to injury caused by acoustic trauma
or ototoxicity, but the nature of the interaction between macrophages and the sensory …

Mammalian cochlear outer hair cells (OHCs) are essential for hearing. Severe hearing
impairment follows OHC degeneration. Previous attempts at regenerating new OHCs from …

Neurons that process sensory information exhibit bursts of electrical activity during
development, providing early training to circuits that will later encode similar features of the …

Cortical development extensively depends on sensory experience. Effects of congenital
monaural and binaural deafness on cortical aural dominance and representation of binaural …