Tissue repair after trauma and infection has always been a difficult problem in regenerative
medicine. Hydrogels have become one of the most important scaffolds for tissue …

Stem cells interpret signals from their microenvironment while simultaneously modifying the
niche through secreting factors and exerting mechanical forces. Many soluble stem cell cues …

The spatial presentation of mechanical information is a key parameter for cell behavior. We
have developed a method of polymerization control in which the differential diffusion …

Extracellular biophysical cues have a profound influence on a wide range of cell behaviors,
including growth, motility, differentiation, apoptosis, gene expression, adhesion, and signal …

Biodegradable orthopedic implants, designed to promote vigorous bone healing and be
safely absorbed by the body, are developing rapidly to complement the deficiency of …

Background aims To facilitate artificial bone construct integration into a patient's body,
scaffolds are enriched with different biologically active molecules. Among various scaffold …

Extracellular matrix (ECM) stiffness regulates the lineage commitment of mesenchymal stem
cells (MSCs). Although cells sense ECM stiffness through focal adhesions, how cells sense …

Fibrillar adhesions are important structural and adhesive components in fibroblasts, and are
required for fibronectin fibrillogenesis. While nascent and focal adhesions are known to …

Long non-coding RNAs (lncRNAs) play pivotal roles in mesenchymal stem cell
differentiation. However, the mechanisms by which non-coding RNA (ncRNA) networks …

Stem cells have attracted much attention in the field of regeneration due to their unique
ability to promote regeneration. Among the many approaches used to regulate directed …