Extracting research-quality phenotypes from electronic health records to support precision medicine

WQ Wei, JC Denny - Genome medicine, 2015 - Springer
The convergence of two rapidly developing technologies-high-throughput genotyping and
electronic health records (EHRs)-gives scientists an unprecedented opportunity to utilize …

Synthea: An approach, method, and software mechanism for generating synthetic patients and the synthetic electronic health care record

J Walonoski, M Kramer, J Nichols… - Journal of the …, 2018 - academic.oup.com
Objective Our objective is to create a source of synthetic electronic health records that is
readily available; suited to industrial, innovation, research, and educational uses; and free of …

Changes in the incidence, prevalence and mortality of bronchiectasis in the UK from 2004 to 2013: a population-based cohort study

JK Quint, ERC Millett, M Joshi… - European …, 2015 - publications.ersnet.org
There is a paucity of data on incidence, prevalence and mortality associated with non-cystic
fibrosis bronchiectasis. Using the Clinical Practice Research Datalink for participants …

An extension of the technology acceptance model in the big data analytics system implementation environment

S Verma, SS Bhattacharyya, S Kumar - Information Processing & …, 2018 - Elsevier
Research on the adoption of systems for big data analytics has drawn enormous attention in
Information Systems research. This study extends big data analytics adoption research by …

Delay in treatment intensification increases the risks of cardiovascular events in patients with type 2 diabetes

SK Paul, K Klein, BL Thorsted, ML Wolden… - Cardiovascular …, 2015 - Springer
Background The aim of the study was to evaluate the effect of delay in treatment
intensification (IT; clinical inertia) in conjunction with glycaemic burden on the risk of …

Factors influencing the development of primary care data collection projects from electronic health records: a systematic review of the literature

ML Gentil, M Cuggia, L Fiquet, C Hagenbourger… - BMC medical informatics …, 2017 - Springer
Background Primary care data gathered from Electronic Health Records are of the utmost
interest considering the essential role of general practitioners (GPs) as coordinators of …

Clinical inertia with regard to intensifying therapy in people with type 2 diabetes treated with basal insulin

K Khunti, A Nikolajsen, BL Thorsted… - Diabetes, Obesity …, 2016 - Wiley Online Library
Aim To investigate whether clinical inertia, the failure to intensify treatment regimens when
required, exists in people with type 2 diabetes treated with basal insulin. Methods This was a …

Validation of chronic obstructive pulmonary disease recording in the Clinical Practice Research Datalink (CPRD-GOLD)

JK Quint, H Müllerova, RL DiSantostefano, H Forbes… - BMJ open, 2014 - bmjopen.bmj.com
Objectives The optimal method of identifying people with chronic obstructive pulmonary
disease (COPD) from electronic primary care records is not known. We assessed the …

Risk factors for acute exacerbations of COPD in a primary care population: a retrospective observational cohort study

H Müllerová, A Shukla, A Hawkins, J Quint - BMJ open, 2014 - bmjopen.bmj.com
Objectives To evaluate risk factors associated with exacerbation frequency in primary care.
Information on exacerbations of chronic obstructive pulmonary disease (COPD) has mainly …

Embedding electronic health records onto a knowledge network recognizes prodromal features of multiple sclerosis and predicts diagnosis

CA Nelson, R Bove, AJ Butte… - Journal of the American …, 2022 - academic.oup.com
Objective Early identification of chronic diseases is a pillar of precision medicine as it can
lead to improved outcomes, reduction of disease burden, and lower healthcare costs …