Protein-protein interactions (PPIs) are well-established as a class of promising drug targets
for their implications in a wide range of biological processes. However, drug development …

Unlike natural macromolecules (eg, nucleic acids and proteins) possessing precisely
defined molar mass, chain sequence, chirality, and topology, synthetic polymers are typically …

Unnatural helical peptidic foldamers have attracted considerable attention owing to their
unique folding behaviours, diverse artificial protein binding mechanisms, and promising …

ABSTRACT Background Protein-protein interactions (PPIs) are intriguing targets for
designing novel small-molecule inhibitors. The role of PPIs in various infectious and …

Angiogenesis, formation of new blood vessels from the existing vascular network, is a
hallmark of cancer cells that leads to tumor vascular proliferation and metastasis. This …

Sequence-controlled polymers are an emerging class of synthetic polymers with a regulated
sequence of monomers. In the past decade, tremendous progress has been made in the …

The development of potent, specific, and pharmacologically viable chemical probes and
therapeutics is a central focus of chemical biology and therapeutic development. However, a …

Conspectus Foldamers have defined and predictable structures, improved resistance to
proteolytic degradation, enhanced chemical diversity, and are versatile in their mimicry of …

The development of inhibitors that selectively block protein–protein interactions (PPIs) is
crucial for chemical biology, medicinal chemistry, and biomedical sciences. Herein, we …

Gastric carcinoma is a highly malignant tumor that still lacks effective molecular targets.
Heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) is an essential oncogenic …