The excitatory neurotransmission of the central nervous system (CNS) mainly involves
glutamate and its receptors, especially N-methyl-D-Aspartate receptors (NMDARs). These …

Despite having disease-specific pathologic features and symptoms, neurodegenerative
diseases share common mechanisms, such as excitotoxicity, neuroinflammation, and …

Modulation of miRNAs and neutrophil extracellular traps (NETs) formation are both
implicated in inflammatory disorders. Adult-onset Still's disease (AOSD) is a systemic …

The process of proplatelet formation (PPF) requires coordinated interaction between
megakaryocytes (MKs) and the extracellular matrix (ECM), followed by a dynamic …

Neutrophils play a critical role in immune defense as the first recruited and most abundant
leukocytes in the innate immune system. As such, regulation of neutrophil effector functions …

Behavior and cognition are multifaceted processes influenced by genetics, synaptic
plasticity, and neuronal connectivity. Recent reports have demonstrated that peripheral …

Ionotropic glutamate receptors include α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic
acid receptors (AMPAR), kainate receptors (KAR), and N-methyl-D-aspartate receptors …

Background The effects of a solitary neonatal exposure to anesthesia plus surgery
(anesthesia/surgery) on cognitive function and the underlying mechanism in developing …

Neurological and neuropsychiatric disorders are one of the leading causes of disability
worldwide and affect the health of billions of people. Nitric oxide (NO), a free gas with …

Intracellular calcium signaling regulates diverse physiological and pathological processes.
In solid tumors, changes to calcium channels and effectors via mutations or changes in …