Spine dynamics in the brain, mental disorders and artificial neural networks

H Kasai, NE Ziv, H Okazaki, S Yagishita… - Nature Reviews …, 2021 - nature.com
In the brain, most synapses are formed on minute protrusions known as dendritic spines.
Unlike their artificial intelligence counterparts, spines are not merely tuneable memory …

Autism spectrum disorder: neuropathology and animal models

M Varghese, N Keshav, S Jacot-Descombes… - Acta …, 2017 - Springer
Autism spectrum disorder (ASD) has a major impact on the development and social
integration of affected individuals and is the most heritable of psychiatric disorders. An …

[HTML][HTML] Microglia require CD4 T cells to complete the fetal-to-adult transition

E Pasciuto, OT Burton, CP Roca, V Lagou, WD Rajan… - Cell, 2020 - cell.com
The brain is a site of relative immune privilege. Although CD4 T cells have been reported in
the central nervous system, their presence in the healthy brain remains controversial, and …

Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution

R Gao, SM Asano, S Upadhyayula, I Pisarev, DE Milkie… - Science, 2019 - science.org
INTRODUCTION Neural circuits across the brain are composed of structures spanning
seven orders of magnitude in size that are assembled from thousands of distinct protein …

Excitatory/inhibitory balance and circuit homeostasis in autism spectrum disorders

SB Nelson, V Valakh - Neuron, 2015 - cell.com
Autism spectrum disorders (ASDs) and related neurological disorders are associated with
mutations in many genes affecting the ratio between neuronal excitation and inhibition …

Spine dynamics: are they all the same?

KP Berry, E Nedivi - Neuron, 2017 - cell.com
Since Cajal's first drawings of Golgi stained neurons, generations of researchers have been
fascinated by the small protrusions, termed spines, studding many neuronal dendrites. Most …

Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders

R Gao, P Penzes - Current molecular medicine, 2015 - ingentaconnect.com
Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlapping behavioral phenotypes, which suggests …

Dendritic spines: Revisiting the physiological role

SB Chidambaram, AG Rathipriya, SR Bolla… - Progress in Neuro …, 2019 - Elsevier
Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …

Fundamental elements in autism: from neurogenesis and neurite growth to synaptic plasticity

J Gilbert, HY Man - Frontiers in cellular neuroscience, 2017 - frontiersin.org
Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders with a high
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …

mTOR in brain physiology and pathologies

J Bockaert, P Marin - Physiological reviews, 2015 - journals.physiology.org
TOR (target of rapamycin) and its mammalian ortholog mTOR have been discovered in an
effort to understand the mechanisms of action of the immunosuppressant drug rapamycin …