In spite of the remarkable progress in basic and preclinical studies of acute myeloid
leukemia (AML), the five-year survival rate of AML patients remains poor, highlighting the …

Acute myeloid leukemia (AML) is a heterogeneous disease characterized by the expansion
of immature myeloid cells in the bone marrow (BM) and peripheral blood (PB) resulting in …

Like normal hematopoietic stem cells, leukemic stem cells depend on their bone marrow
(BM) microenvironment for survival, but the underlying mechanisms remain largely …

Cytokines exert profound effects on the progression of hematopoietic malignancies such as
acute myeloid leukemia (AML). Critical roles of cytokines in the context of inflammation have …

Hematopoietic stem cells (HSC) are responsible for the production of mature blood cells. To
ensure that the HSC pool does not get exhausted over the lifetime of an individual, most …

Bone marrow mesenchymal stromal cells (MSCs) constitute one of the important
components of the hematopoietic microenvironmental niche. In vivo studies have shown that …

Mesenchymal stromal cells (MSCs) are essential elements of the bone marrow (BM)
microenvironment, which have been widely implicated in pathways that contribute to …

Mesenchymal stromal cells (MSCs) possess several fairly unique properties that, when
combined, make them ideally suited for cellular-based immunotherapy and as vehicles for …

Abstract Background Mesenchymal stromal cells (MSCs) are an essential element of the
bone marrow (BM) microenvironment, playing a crucial function in regulating hematopoietic …

Acute myeloid leukemias (AML) comprise a wide array of different entities, which have in
common a rapid expansion of myeloid blast cells leading to displacement of normal …