Practical recommendations for using ctDNA in clinical decision making

SA Cohen, MC Liu, A Aleshin - Nature, 2023 - nature.com
The continuous improvement in cancer care over the past decade has led to a gradual
decrease in cancer-related deaths. This is largely attributed to improved treatment and …

Practical considerations for the use of circulating tumor DNA in the treatment of patients with cancer: a narrative review

MG Krebs, U Malapelle, F André, L Paz-Ares… - JAMA …, 2022 - jamanetwork.com
Importance Personalized medicine based on tumor profiling and identification of actionable
genomic alterations is pivotal in cancer management. Although tissue biopsy is still …

[HTML][HTML] Clinical significance and biology of circulating tumor DNA in high-risk early-stage HER2-negative breast cancer receiving neoadjuvant chemotherapy

MJM Magbanua, LB Swigart, Z Ahmed, RW Sayaman… - Cancer cell, 2023 - cell.com
Circulating tumor DNA (ctDNA) analysis may improve early-stage breast cancer treatment
via non-invasive tumor burden assessment. To investigate subtype-specific differences in …

Prognostic value of ctDNA detection in patients with early breast cancer undergoing neoadjuvant therapy: A systematic review and meta-analysis

A Papakonstantinou, NS Gonzalez, I Pimentel… - Cancer treatment …, 2022 - Elsevier
Circulating tumor DNA (ctDNA) is increasingly being used as a biomarker in early breast
cancer (EBC). We performed a systematic review and meta-analysis to investigate the …

Current and emerging applications of droplet digital PCR in oncology: an updated review

S Olmedillas-López, R Olivera-Salazar… - Molecular Diagnosis & …, 2022 - Springer
In the era of personalized medicine and targeted therapies for the management of patients
with cancer, ultrasensitive detection methods for tumor genotyping, such as next-generation …

[HTML][HTML] Circulating biomarkers in breast cancer

KN Seale, KHR Tkaczuk - Clinical breast cancer, 2022 - Elsevier
Breast cancer management has progressed immensely over the decades, but the disease is
still a major source of morbidity and mortality worldwide. Even with enhanced imaging …

The clinical utility of droplet digital PCR for profiling circulating tumor DNA in breast cancer patients

U Gezer, AJ Bronkhorst, S Holdenrieder - Diagnostics, 2022 - mdpi.com
Breast cancer is the most common cancer affecting women worldwide. It is a malignant and
heterogeneous disease with distinct molecular subtypes, which has prognostic and …

Current and developing liquid biopsy techniques for breast cancer

HJ Wu, PY Chu - Cancers, 2022 - mdpi.com
Simple Summary Breast cancer is the most common cancer and leading cause of death
worldwide. Therefore, it is important to diagnose and treat breast cancer early. Current …

Genetics of hepatocellular carcinoma: from tumor to circulating DNA

C Campani, J Zucman-Rossi, JC Nault - Cancers, 2023 - mdpi.com
Simple Summary In recent years, the genetic landscape of hepatocellular carcinoma (HCC)
has been explored, identifying TERT promoter, CTNNB1, and TP53 as the most frequent …

Early identification of disease progression in ALK-rearranged lung cancer using circulating tumor DNA analysis

AK Angeles, P Christopoulos, Z Yuan, S Bauer… - NPJ Precision …, 2021 - nature.com
Targeted kinase inhibitors improve the prognosis of lung cancer patients with ALK
alterations (ALK+). However, due to the emergence of acquired resistance and varied …