Engineering yeast for the production of plant terpenoids using synthetic biology approaches

JA Bureau, ME Oliva, Y Dong, C Ignea - Natural Product Reports, 2023 - pubs.rsc.org
Covering: 2011–2022 The low amounts of terpenoids produced in plants and the difficulty in
synthesizing these complex structures have stimulated the production of terpenoid …

DCEO biotechnology: tools to design, construct, evaluate, and optimize the metabolic pathway for biosynthesis of chemicals

X Chen, C Gao, L Guo, G Hu, Q Luo, J Liu… - Chemical …, 2018 - ACS Publications
Chemical synthesis is a well established route for producing many chemicals on a large
scale, but some drawbacks still exist in this process, such as unstable intermediates …

Improving the phenotype predictions of a yeast genome‐scale metabolic model by incorporating enzymatic constraints

BJ Sánchez, C Zhang, A Nilsson… - Molecular systems …, 2017 - embopress.org
Genome‐scale metabolic models (GEM s) are widely used to calculate metabolic
phenotypes. They rely on defining a set of constraints, the most common of which is that the …

A synthetic biochemistry platform for cell free production of monoterpenes from glucose

TP Korman, PH Opgenorth, JU Bowie - Nature communications, 2017 - nature.com
Cell-free systems designed to perform complex chemical conversions of biomass to biofuels
or commodity chemicals are emerging as promising alternatives to the metabolic …

Engineering plant secondary metabolism in microbial systems

ME Pyne, L Narcross, VJJ Martin - Plant physiology, 2019 - academic.oup.com
Engineering Plant Secondary Metabolism in Microbial Systems | Plant Physiology | Oxford
Academic Skip to Main Content Advertisement Oxford Academic Journals Books Search Menu …

The road to biorenewables: carbohydrates to commodity chemicals

RA Sheldon - ACS Sustainable Chemistry & Engineering, 2018 - ACS Publications
The pressing need for climate change mitigation has focused attention on reducing global
emissions of carbon dioxide by effectuating the transition from fossil-based chemicals …

Engineering chimeric diterpene synthases and isoprenoid biosynthetic pathways enables high-level production of miltiradiene in yeast

T Hu, J Zhou, Y Tong, P Su, X Li, Y Liu, N Liu, X Wu… - Metabolic …, 2020 - Elsevier
Miltiradiene is a key intermediate in the biosynthesis of many important natural diterpene
compounds with significant pharmacological activity, including triptolide, tanshinones …

[HTML][HTML] Metabolic engineering and synthetic biology of plant natural products–A minireview

AS Birchfield, CA McIntosh - Current Plant Biology, 2020 - Elsevier
Plant natural products include a diverse array of compounds that play important roles in
plant metabolism and physiology. After elucidation of biosynthetic pathways and regulatory …

Metabolic engineering and synthetic biology for isoprenoid production in Escherichia coli and Saccharomyces cerevisiae

GR Navale, MS Dharne, SS Shinde - Applied Microbiology and …, 2021 - Springer
Isoprenoids, often called terpenoids, are the most abundant and highly diverse family of
natural organic compounds. In plants, they play a distinct role in the form of photosynthetic …

Engineering plant sesquiterpene synthesis into yeasts: a review

J Mai, W Li, R Ledesma-Amaro… - Journal of Agricultural and …, 2021 - ACS Publications
Sesquiterpenes are natural compounds composed of three isoprene units. They represent
the largest class of terpene compounds found in plants, and many have remarkable …