Background: Mean platelet volume (MPV) is arousing increasing interest as a new
independent cardiovascular risk factor. Aim: To provide a comprehensive review on the …

The CBC count and leukocyte differential count (LDC) are among the most frequently
requested clinical laboratory tests. These analyses are highly automated, and the correct …

Modern cell analyzers routinely produce platelet indices, but many clinicians do not utilize
them in clinical decision-making. In part this can be attributed to difficulties with their …

ALTHOUGH THE CONCEPT was advanced some 37 years ago, evidence for the existence
of a humoral regulator of platelet production, first termed thrombopoietin (Tpo) by Kelemen …

To study the effects of cigarette smoking and atherosclerosis on platelet size, we measured
the mean platelet volume (MPV) and other platelet parameters in 142 elderly smokers and …

The response of cells of the murine megakaryocytic lineage to human interleukin 6 (IL-6)
was assessed in serum-depleted cultures using a variety of biological assays. IL-6 alone …

Thrombopoietin (Tpo), the ligand for the c-mpl receptor, is a major regulator of platelet
production in vivo. Treatment of mice with purified recombinant Tpo increases platelet count …

Platelets and coagulation factors are involved in the process of haemostasis, which ensures
undisturbed blood flow upon vessel wall damage. However, excessive platelet aggregation …

After the first description of platelets more than a century ago, the knowledge about their
origin and function grew continuously. The development of the impedance method as a …

Platelets are causally involved in coronary artery obstruction in acute coronary syndromes
(ACS). This cell type is unique to mammals and its production, which is unlike that of any …