The sites of targeted therapy are limited and need to be expanded. The FGF‐FGFR
signalling plays pivotal roles in the oncogenic process, and FGF/FGFR inhibitors are a …

Fibroblast growth factors (FGF) and their receptors serve many functions in both the
developing and adult organism. Humans contain 18 FGF ligands and four FGF receptors …

Introduction: Deregulation of the fibroblast growth factor (FGF)/FGF receptor (FGFR) network
occurs frequently in tumors due to gene amplification, activating mutations, and oncogenic …

Dysregulated fibroblast growth factor receptor (FGFR) signaling is associated with several
cancers, including urothelial carcinoma. Preclinical studies with FGFR inhibitors have shown …

Fibroblast growth factor receptor (FGFR) genetic alterations are frequently observed in
cancer, suggesting that FGFR inhibition may be a promising therapy in patients harboring …

Fibroblast growth factor receptor-3 (FGFR3) is a receptor tyrosine kinase implicated in the
tumorigenesis of multiple malignancies, including bladder and other urothelial cancers …

Simple Summary In the present study, we aimed to construct a methylation diagnostic tool
using urine sediment for the detection of urothelial bladder carcinoma (UBC), and improved …

Malignant Brenner tumor is a rare primary ovarian carcinoma subtype that may present
diagnostic and therapeutic conundrums. Here, we characterize the genomics of 11 …

Mutations in the fibroblast growth factor receptor-3 (FGFR3) gene are frequently found in
bladder cancer, but their prognostic value remains controversial. To globally summarize the …

Background and aims The spatial and temporal genetic heterogeneity of bladder cancer
(BC) makes challenging to find specific drivers of metastatic disease, thus preventing to …