Women taking a folic acid supplement in countries with mandatory food fortification programs may be exceeding the upper tolerable limit of folic acid: A systematic …

C Ledowsky, A Mahimbo, V Scarf, A Steel - Nutrients, 2022 - mdpi.com
Background: In preconception and pregnancy, women are encouraged to take folic acid-
based supplements over and above food intake. The upper tolerable limit of folic acid is …

Folic acid, folinic acid, 5 methyl tetrahydrofolate supplementation for mutations that affect epigenesis through the folate and one-carbon cycles

Y Menezo, K Elder, A Clement, P Clement - Biomolecules, 2022 - mdpi.com
Methylation is an essential biochemical mechanism that is central to the transmission of life,
and crucially responsible for regulating gametogenesis and continued embryo development …

Human milk unmetabolized folic acid is increased following supplementation with synthetic folic acid as compared to (6S)-5-methyltetrahydrofolic acid

KM Cochrane, R Elango, AM Devlin, JA Hutcheon… - Scientific Reports, 2023 - nature.com
Folic acid supplementation is recommended perinatally, but may increase unmetabolized
folic acid (UMFA) in human milk; this is concerning as it is an inactive form which may be …

Supplementation with (6S)-5-methyltetrahydrofolic acid appears as effective as folic acid in maintaining maternal folate status while reducing unmetabolised folic acid …

KM Cochrane, R Elango, AM Devlin, C Mayer… - British Journal of …, 2024 - cambridge.org
Folic acid supplementation is recommended during pregnancy to support healthy fetal
development;(6S)-5-methyltetrahydrofolic acid ((6S)-5-MTHF) is available in some …

Folate dose and form during pregnancy may program maternal and fetal health and disease risk

E Pannia, R Hammoud, R Simonian, R Kubant… - Nutrition …, 2022 - academic.oup.com
The role of folate, in its synthetic and bioactive form, as an in utero modifier of metabolic
outcomes in mothers and offspring is examined in this review. During pregnancy, a …

[HTML][HTML] Iron-deficiency prevalence and supplementation practices among pregnant women: a secondary data analysis from a clinical trial in Vancouver, Canada

KM Cochrane, JA Hutcheon, CD Karakochuk - The Journal of nutrition, 2022 - Elsevier
ABSTRACT Background North American public health guidelines recommend
supplementation with an iron-containing prenatal multivitamin throughout pregnancy to meet …

[HTML][HTML] Variations in folate prescriptions for patients with the MTHFR genetic polymorphisms: A case series study

CJ Ledowsky, J Schloss, A Steel - … research in clinical and social pharmacy, 2023 - Elsevier
Background Over 48.5 million couples are reported with infertility worldwide. Health policy
recommends folic acid in women of childbearing age, particularly in preconception and …

Anti-inflammatory effects of 6S-5-methyltetrahydrofolate‐calcium on RAW264. 7 cells and zebrafish

XN Bin, YB Gao, M Pan, ZL Lian, YZ Cheng, JQ Wu… - Life Sciences, 2023 - Elsevier
Abstract Aim 6S-5-methyltetrahydrofolate is the predominant form of dietary folate in
circulation and is used as a crystalline form of calcium salt (MTHF-Ca). Reports revealed that …

[6S]-5-Methyltetrahydrofolic Acid and Folic Acid Pregnancy Diets Differentially Program Metabolic Phenotype and Hypothalamic Gene Expression of Wistar Rat Dams …

E Pannia, R Hammoud, R Simonian, E Arning… - Nutrients, 2020 - mdpi.com
[6 S]-5-methyltetrahydrofolic acid (MTHF) is a proposed replacement for folic acid (FA) in
diets and prenatal supplements. This study compared the effects of these two forms on …

Human milk oligosaccharide composition following supplementation with folic acid vs (6S)-5-methyltetrahydrofolic acid during pregnancy and mediation by human …

KM Cochrane, JN Bone, CD Karakochuk… - European Journal of …, 2024 - nature.com
Supplementation with folic acid versus (6 S)-5-methyltetrahydrofolic acid (5-MTHF) results in
different folate forms in human milk, with folic acid increasing unmetabolized folic acid …