Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable
cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of …

TRPM7, a divalent cation-selective channel with kinase domains, has been widely reported
to potentially affect cancers. In this study, we conducted multiple bioinformatic analyses …

Local anesthetics are widely used during clinical cancer surgeries. Studies have suggested
that the use and the type of anesthesia affect cancer outcomes. In vivo studies and clinical …

Simple Summary The local anesthetic lidocaine suppresses some cancer cell lines but the
mechanism is unclear. Melastatin-like transient receptor potential 7 (TRPM7) ion channels …

Diabetic retinopathy (DR) manifests as a complicated and blinding complication in diabetes
mellitus. First-line treatments for advanced DR have shown ocular side-effects in some …

Background Tumor cell metabolic reprogramming is crucial for the malignant behavior of
cancer cells by promoting their proliferation. However, little is known on how transient …

As the most prevalent cancer for females, breast cancer is also the second most popular
cancer type overall. More efforts are needed to research new drugs and combination …

Cancer research is profoundly influenced by the complex interplay of gene expression, yet
conventional studies often emphasize genes with high expression levels, potentially …

Epigenetics focuses on DNA methylation, histone modification, chromatin remodeling,
noncoding RNAs, and other gene regulation mechanisms beyond the DNA sequence. In the …

Recent studies suggest a need for reliable biomarkers enhancing prognosis prediction and
treatment strategies in cancer. Here, we performed a data analysis bearing on the …