Breast cancer is the most frequently diagnosed cancer in women and ranks second among
causes for cancer-related death in women. Gene technology has led to the recognition that …

Purpose: We investigated whether a dendritic cell (DC) vaccine transduced with an
adenoviral vector encoded with full-length survivin (Ad-S), with mutations neutralizing its …

Simple Summary Survivin is overexpressed in a wide variety of human cancers and is
associated with increased chemotherapy resistance, recurrence, and shorter patient …

In this study, we explore the role of nuclear survivin in maintaining the effector phenotype of
IFNγ-producing T cells acting through the transcriptional control of glucose utilization. High …

Acute graft-vs.-host disease (GVHD) is an important cause of morbidity and death after
allogeneic hematopoietic cell transplantation (HCT). We identify a new approach to prevent …

Multiple myeloma (MM) treatment remains challenging due to its relapsed/refractory disease
course as well as intra-and inter-patient heterogeneity. Cellular immunotherapies, especially …

Extramedullary multiple myeloma (EMM) is defined as the presence of plasma cells outside
the bone marrow of multiple myeloma patients, and its prognosis is poor. High-dose …

Interferon-gamma (IFNγ) producing T cells develop metabolic adaptation required for their
effector functions in tumour biology, autoimmunity and antiviral defence. Using sorted CD4+ …

Non‐dysplastic Barrett's oesophagus (NDBE) occurs as a consequence of an inflammatory
response triggered through prolonged gastro‐oesophageal reflux and it may precede the …

The invention concerns a variant (double mutant form) of the survivin polypeptide; nucleic
acid molecules encoding the survivin variant; antigen presenting cells (APCs) such as …