Therapeutic resistance and metastatic progression are responsible for the majority of cancer
mortalities. In particular, the development of resistance is a significant barrier to the efficacy …

Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable
cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of …

Background Metastasis of breast cancer have caused the majority of cancer-related death
worldwide. The circRNAs are associated with tumorigenesis and metastasis in breast cancer …

Drug-tolerant persister cells (persisters) evade apoptosis upon targeted and conventional
cancer therapies and represent a major non-genetic barrier to effective cancer treatment …

Integrating whole-slide images (WSIs) and bulk transcriptomics for predicting patient survival
can improve our understanding of patient prognosis. However this multimodal task is …

Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year overall survival rate. Patients
with PDAC display limited benefits after undergoing chemotherapy or immunotherapy …

Background Chemotherapy resistance is a primary reason of ovarian cancer therapy failure;
hence it is important to investigate the underlying mechanisms of chemotherapy resistance …

Chronic stress is associated with increased risk of metastasis and poor survival in cancer
patients, yet the reasons are unclear. We show that chronic stress increases lung metastasis …

Epithelial cells acquire mesenchymal phenotypes through epithelial‐mesenchymal
transition (EMT) during cancer progression. However, how epithelial cells retain their …

Background Breast cancer (BC) is the second most frequent type of cancer in the world and
most common among women, configuring a major challenge to global health. BC is a …