Purine nucleosides interfere with c-di-AMP levels and act as adjuvants to re-sensitize MRSA to β-lactam antibiotics
AC Nolan, MS Zeden, I Kviatkovski, C Campbell… - Mbio, 2023 - Am Soc Microbiol
The purine-derived signaling molecules c-di-AMP and (p) ppGpp control mecA/PBP2a-
mediated β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) raise …
mediated β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) raise …
Metabolic reprogramming and altered cell envelope characteristics in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics
Central metabolic pathways control virulence and antibiotic resistance, and constitute
potential targets for antibacterial drugs. In Staphylococcus aureus the role of the pentose …
potential targets for antibacterial drugs. In Staphylococcus aureus the role of the pentose …
Accumulation of Succinyl Coenzyme A Perturbs the Methicillin-Resistant Staphylococcus aureus (MRSA) Succinylome and Is Associated with Increased Susceptibility …
Penicillin binding protein 2a (PBP2a)-dependent resistance to β-lactam antibiotics in
methicillin-resistant Staphylococcus aureus (MRSA) is regulated by the activity of the …
methicillin-resistant Staphylococcus aureus (MRSA) is regulated by the activity of the …
[HTML][HTML] Metabolic reprogramming and flux to cell envelope precursors in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics
Central metabolic pathways controls virulence and antibiotic resistance, and constitute
potential targets for antibacterial drugs. In Staphylococcus aureus the role of the pentose …
potential targets for antibacterial drugs. In Staphylococcus aureus the role of the pentose …