Complement component C3–The “Swiss Army Knife” of innate immunity and host defense
As a preformed defense system, complement faces a delicate challenge in providing an
immediate, forceful response to pathogens even at first encounter, while sparing host cells in …
immediate, forceful response to pathogens even at first encounter, while sparing host cells in …
Compstatins: the dawn of clinical C3-targeted complement inhibition
Despite the growing recognition of the complement system as a major contributor to a variety
of clinical conditions, the therapeutic arsenal has remained scarce. The introduction of an …
of clinical conditions, the therapeutic arsenal has remained scarce. The introduction of an …
A novel C5a receptor-tissue factor cross-talk in neutrophils links innate immunity to coagulation pathways
K Ritis, M Doumas, D Mastellos, A Micheli… - The Journal of …, 2006 - journals.aai.org
Neutrophils and complement are key sentinels of innate immunity and mediators of acute
inflammation. Recent studies have suggested that inflammatory processes modulate …
inflammation. Recent studies have suggested that inflammatory processes modulate …
Advances in protein structure prediction and de novo protein design: A review
CA Floudas, HK Fung, SR McAllister… - Chemical Engineering …, 2006 - Elsevier
This review provides an exposition to the important problems of (i) structure prediction in
protein folding and (ii) de novo protein design. The recent advances in protein folding are …
protein folding and (ii) de novo protein design. The recent advances in protein folding are …
[HTML][HTML] Complement component C3: a structural perspective and potential therapeutic implications
As the most abundant component of the complement system, C3 and its proteolytic
derivatives serve essential roles in the function of all three complement pathways. Central to …
derivatives serve essential roles in the function of all three complement pathways. Central to …
Complement‐targeted therapeutics: an emerging field enabled by academic drug discovery
Within a short few years, the number of complement inhibitors that are either approved for
therapeutic application or evaluated in late‐stage clinical trials has expanded remarkably …
therapeutic application or evaluated in late‐stage clinical trials has expanded remarkably …
Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis
Beyond its role in immunity, complement mediates a wide range of functions in the context of
morphogenetic or tissue remodeling processes. Angiogenesis is crucial during tissue …
morphogenetic or tissue remodeling processes. Angiogenesis is crucial during tissue …
Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors
With the addition of the compstatin-based complement C3 inhibitor pegcetacoplan, another
class of complement targeted therapeutics have recently been approved. Moreover …
class of complement targeted therapeutics have recently been approved. Moreover …
Compstatin: a complement inhibitor on its way to clinical application
D Ricklin, JD Lambris - Current Topics in Complement II, 2008 - Springer
Therapeutic modulation of the human complement system is considered a promising
approach for treating a number of pathological conditions. Owing to its central position in the …
approach for treating a number of pathological conditions. Owing to its central position in the …
[HTML][HTML] New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties
Therapeutic modulation of the complement system has become increasingly important in
line with the growing recognition of the role of complement in numerous diseases …
line with the growing recognition of the role of complement in numerous diseases …