Immune checkpoint blockade (ICB) is a promising therapy for solid tumors, but its
effectiveness depends on biomarkers that are not precise. Here, we utilized genome-wide …

Cordyceps sinensis (CS) has been widely used as a dietary supplement or traditional
medicine for the prevention, treatment, and prognostication of various diseases, because of …

GATA4 is a transcription factor known for its crucial role in the development of many tissues,
including the liver; however, its role in adult liver metabolism is unknown. Here, using high …

Background and purpose Genome-wide association studies (GWAS) of metabolic syndrome
(MetS) have predominantly focused on non-Asian populations, with limited representation …

Maternal obesity and hyperglycemia are linked to an elevated risk for obesity, diabetes, and
steatotic liver disease in the adult offspring. To establish and validate a noninvasive …

Background The prevalence of diabetic dyslipidemia has gradually increased worldwide
and individuals with hypertriglyceridemia often have a high polygenic burden of triglyceride …

Study Design. A 2-sample Mendelian randomization (MR) analysis. Objective. This study
aimed to investigate the association between genetically predicted hyperlipidemia and …

Background: Apolipoprotein A5 (APOA5) is involved in serum triglyceride (TG) regulation.
Several studies have reported that the rs651821 locus in the APOA5 gene is associated with …

Primary hypertriglyceridemia (PHTG) is characterized by a high concentration of
triglycerides (TG); it is divided between familial hyperchylomicronemia syndrome and …

Liver is a key regulator of systemic metabolism in physiology and pathology. It maintains
cholesterol, triglyceride and glucose homeostasis in response to fasting and feeding …