Heparin has been used extensively as an antithrombotic and anticoagulant for close to 100
years. This anticoagulant activity is attributed mainly to the pentasaccharide sequence …

Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy
caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. Pathogenic …

Background Heparin-induced thrombocytopenia (HIT) is an antibody-mediated adverse
drug reaction that can lead to devastating thromboembolic complications, including …

Heparin-induced thrombocytopenia is a profoundly dangerous, potentially lethal,
immunologically mediated adverse drug reaction to unfractionated heparin or, less …

This chapter about the recognition, treatment, and prevention of heparin-induced
thrombocytopenia (HIT) is part of the Antithrombotic and Thrombolytic Therapy: American …

Thrombosis has long been recognized as a potentially lifethreatening complication in
children with congenital heart disease (CHD), children with acquired heart disease, and in …

There are currently no effective substitutes for high intensity therapy with unfractionated
heparin (UFH) for cardiovascular procedures based on its rapid onset of action, ease of …

Few laboratory tests are as clinically useful as The platelet serotonin‐release assay (SRA): a
positive SRA in the appropriate clinical context is virtually diagnostic of heparin‐induced …

Background: Many laboratories test for heparin‐induced thrombocytopenia (HIT) using a
PF4‐dependent enzyme‐immunoassay (EIA). An advantage of the EIA is its simplicity; a …

Immunoassays are essential in the workup of patients with suspected heparin-induced
thrombocytopenia. However, the diagnostic accuracy is uncertain with regard to different …