Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam
To examine the transmission dynamics of Mycobacterium tuberculosis (Mtb) isolated from
tuberculosis patients in Ho Chi Minh City, Vietnam, we sequenced the whole genomes of …
tuberculosis patients in Ho Chi Minh City, Vietnam, we sequenced the whole genomes of …
Effectiveness and safety of levofloxacin containing regimen in the treatment of Isoniazid mono-resistant pulmonary tuberculosis: A systematic review
Background We aimed to determine the effectiveness and safety of the Levofloxacin-
containing regimen that the World Health Organization is currently recommending for the …
containing regimen that the World Health Organization is currently recommending for the …
Empirical ways to identify novel Bedaquiline resistance mutations in AtpE
Clinical resistance against Bedaquiline, the first new anti-tuberculosis compound with a
novel mechanism of action in over 40 years, has already been detected in Mycobacterium …
novel mechanism of action in over 40 years, has already been detected in Mycobacterium …
Identification of bacterial determinants of tuberculosis infection and treatment outcomes: a phenogenomic analysis of clinical strains
S Stanley, CN Spaulding, Q Liu, MR Chase… - The Lancet …, 2024 - thelancet.com
Background Bacterial diversity could contribute to the diversity of tuberculosis infection and
treatment outcomes observed clinically, but the biological basis of this association is poorly …
treatment outcomes observed clinically, but the biological basis of this association is poorly …
Endogenous relapse and exogenous reinfection in recurrent pulmonary tuberculosis: A retrospective study revealed by whole genome sequencing
W He, Y Tan, Z Song, B Liu, Y Wang, P He… - Frontiers in …, 2023 - frontiersin.org
Background Tuberculosis may reoccur due to reinfection or relapse after initially successful
treatment. Distinguishing the cause of TB recurrence is crucial to guide TB control and …
treatment. Distinguishing the cause of TB recurrence is crucial to guide TB control and …
MUC5AC Genetic Variation Is Associated With Tuberculous Meningitis Cerebral Spinal Fluid Cytokine Responses and Mortality
MC Sabo, NTT Thuong, X Chang… - The Journal of …, 2023 - academic.oup.com
Background The purpose of this study was to assess if single nucleotide polymorphisms
(SNPs) in lung mucins MUC5B and MUC5AC are associated with Mycobacterium …
(SNPs) in lung mucins MUC5B and MUC5AC are associated with Mycobacterium …
Sources of multidrug resistance in patients with previous isoniazid-resistant tuberculosis identified using whole genome sequencing: A longitudinal cohort study
V Srinivasan, VTN Ha, DN Vinh… - Clinical Infectious …, 2020 - academic.oup.com
Background Meta-analysis of patients with isoniazid-resistant tuberculosis (TB) given
standard first-line anti-TB treatment indicated an increased risk of multidrug-resistant TB …
standard first-line anti-TB treatment indicated an increased risk of multidrug-resistant TB …
Analysis of serial multidrug-resistant tuberculosis strains causing treatment failure and within-host evolution by whole-genome sequencing
X Chen, G He, S Lin, S Wang, F Sun, J Chen, W Zhang - Msphere, 2020 - Am Soc Microbiol
The cure rate of multidrug-resistant tuberculosis (MDR-TB) is relatively low in China. The
reasons for the treatment failure and within-host evolution during treatment have not been …
reasons for the treatment failure and within-host evolution during treatment have not been …
Fluoroquinolones and isoniazid-resistant tuberculosis: implications for the 2018 WHO guidance
HR Stagg, GH Bothamley… - European …, 2019 - publications.ersnet.org
Introduction 2018 World Health Organization (WHO) guidelines for the treatment of isoniazid
(H)-resistant (Hr) tuberculosis recommend a four-drug regimen: rifampicin (R), ethambutol …
(H)-resistant (Hr) tuberculosis recommend a four-drug regimen: rifampicin (R), ethambutol …
Disruption of aldehyde dehydrogenase 2 protects against bacterial infection
Abstract The ALDH2* 2 (rs671) allele is one of the most common genetic mutations in
humans, yet the positive evolutionary selective pressure to maintain this mutation is …
humans, yet the positive evolutionary selective pressure to maintain this mutation is …