Anticancer molecular mechanisms of resveratrol
Resveratrol is a pleiotropic phytochemical belonging to the stilbene family. Though it is only
significantly present in grape products, a huge amount of preclinical studies investigated its …
significantly present in grape products, a huge amount of preclinical studies investigated its …
Metabolic control of methylation and acetylation
Highlights•Epigenetic methylation and acetylation are sensitive to cellular metabolic
status.•Diet and environment conditions shape epigenetics through metabolism.•Stem cells …
status.•Diet and environment conditions shape epigenetics through metabolism.•Stem cells …
NAD+ salvage pathway in cancer metabolism and therapy
BE Kennedy, T Sharif, E Martell, C Dai, Y Kim… - Pharmacological …, 2016 - Elsevier
Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme for various
physiological processes including energy metabolism, DNA repair, cell growth, and cell …
physiological processes including energy metabolism, DNA repair, cell growth, and cell …
The bidirectional relationship between cancer epigenetics and metabolism
Metabolic and epigenetic reprogramming are characteristics of cancer cells that, in many
cases, are linked. Oncogenic signaling, diet, and tumor microenvironment each influence …
cases, are linked. Oncogenic signaling, diet, and tumor microenvironment each influence …
Combining integrated genomics and functional genomics to dissect the biology of a cancer‐associated, aberrant transcription factor, the ASPSCR1–TFE3 fusion …
R Kobos, M Nagai, M Tsuda, MY Merl… - The Journal of …, 2013 - Wiley Online Library
Oncogenic rearrangements of the TFE3 transcription factor gene are found in two distinct
human cancers. These include ASPSCR1–TFE3 in all cases of alveolar soft part sarcoma …
human cancers. These include ASPSCR1–TFE3 in all cases of alveolar soft part sarcoma …
Nicotinamide phosphoribosyltransferase (Nampt) in carcinogenesis: new clinical opportunities
ABSTRACT Introduction: Nicotinamide phosphoribosyltransferase (Nampt) is the rate-
limiting enzyme that catalyzes the first step in the mammalian nicotinamide adenine …
limiting enzyme that catalyzes the first step in the mammalian nicotinamide adenine …
Nicotinamide phosphoribosyl transferase (Nampt) is a target of microRNA-26b in colorectal cancer cells
C Zhang, J Tong, G Huang - PloS one, 2013 - journals.plos.org
A number of cancers show increased expression of Nicotinamide phosphoribosyl
transferase (Nampt). However, the mechanism through which Nampt is upregulated is …
transferase (Nampt). However, the mechanism through which Nampt is upregulated is …
Extracellular NAMPT/visfatin causes p53 deacetylation via NAD production and SIRT1 activation in breast cancer cells
Visfatin, which is secreted as an adipokine and cytokine, has been implicated in cancer
development and progression. In this study, we investigated the NAD‐producing ability of …
development and progression. In this study, we investigated the NAD‐producing ability of …
Interrelationships between sirtuin 1 and transcription factors p53 and NF-κB (p50/p65) in the control of ovarian cell apoptosis and proliferation
AV Sirotkin, P Dekanová, AH Harrath… - Cell and Tissue …, 2014 - Springer
The roles of the mTOR system enzyme sirtuin 1 (SIRT1), the transcription factor p53 and the
nuclear factor kappaB (NF-κB) and their interrelationships in the control of ovarian function …
nuclear factor kappaB (NF-κB) and their interrelationships in the control of ovarian function …
Molecular mechanism of CCDC106 regulating the p53-Mdm2/MdmX signaling axis
T Zhou, Z Ke, Q Ma, J Xiang, M Gao, Y Huang… - Scientific Reports, 2023 - nature.com
The tumor suppressor p53 (p53) is regulated by murine double minute 2 (Mdm2) and its
homologous MdmX in maintaining the basal level of p53. Overexpressed Mdm2/MdmX …
homologous MdmX in maintaining the basal level of p53. Overexpressed Mdm2/MdmX …