Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

The past 10 years have seen great advances in our ability to manipulate cell fate, including
the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This …

Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue
of histones and non-histone proteins and regulate the process of transcription by binding to …

Abstract Information storage and retrieval is essential for all life. In biology, information is
primarily stored in two distinct ways: the genome, comprising nucleic acids, acts as a …

Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …

Summary N 6-methyladenosine (m 6 A) has been recently identified as a conserved
epitranscriptomic modification of eukaryotic mRNAs, but its features, regulatory mechanisms …

Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

Neuronal conversion from human fibroblasts can be induced by lineage-specific
transcription factors; however, the introduction of ectopic genes limits the therapeutic …

Memories can be unreliable. We created a false memory in mice by optogenetically
manipulating memory engram–bearing cells in the hippocampus. Dentate gyrus (DG) or …