Drug delivery systems for CRISPR-based genome editors
V Madigan, F Zhang, JE Dahlman - Nature Reviews Drug Discovery, 2023 - nature.com
CRISPR-based drugs can theoretically manipulate any genetic target. In practice, however,
these drugs must enter the desired cell without eliciting an unwanted immune response, so …
these drugs must enter the desired cell without eliciting an unwanted immune response, so …
The extent to which lipid nanoparticles require apolipoprotein E and low-density lipoprotein receptor for delivery changes with ionizable lipid structure
K Paunovska, AJ Da Silva Sanchez… - Nano …, 2022 - ACS Publications
Lipid nanoparticles (LNPs) have delivered therapeutic RNA to hepatocytes in humans.
Adsorption of apolipoprotein E (ApoE) onto these clinical LNP-mRNA drugs has been …
Adsorption of apolipoprotein E (ApoE) onto these clinical LNP-mRNA drugs has been …
Tetrahydropyrimidine Ionizable Lipids for Efficient mRNA Delivery
Lipid nanoparticles (LNPs) have emerged as an effective and promising technology for
messenger RNA (mRNA) delivery, offering a potential solution to physiological barriers and …
messenger RNA (mRNA) delivery, offering a potential solution to physiological barriers and …
Analysis of Nanomedicine Efficacy for Osteoarthritis
Osteoarthritis (OA) is a chronic disease and it causes considerable medical and
socioeconomic burden. Currently, OA can be classified into different stages depending on its …
socioeconomic burden. Currently, OA can be classified into different stages depending on its …
Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection
AE Byrnes, SL Dominguez, CW Yen, BI Laufer… - … Therapy-Nucleic Acids, 2023 - cell.com
Antisense oligonucleotide (ASO) therapeutics are being investigated for a broad range of
neurological diseases. While ASOs have been effective in the clinic, improving productive …
neurological diseases. While ASOs have been effective in the clinic, improving productive …