Antimalarial drug resistance: a threat to malaria elimination

D Menard, A Dondorp - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
Increasing antimalarial drug resistance once again threatens effective antimalarial drug
treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are …

Antimalarial drug resistance in Africa: the calm before the storm?

MD Conrad, PJ Rosenthal - The Lancet Infectious Diseases, 2019 - thelancet.com
Antimalarial drug resistance, in particular resistance to Plasmodium falciparum, challenges
the treatment and control of malaria. In this Review, we summarise evolving patterns of …

Changing prevalence of potential mediators of aminoquinoline, antifolate, and artemisinin resistance across Uganda

V Asua, MD Conrad, O Aydemir… - The Journal of …, 2021 - academic.oup.com
Abstract Background In Uganda, artemether-lumefantrine is recommended for malaria
treatment and sulfadoxine-pyrimethamine for chemoprevention during pregnancy, but drug …

[HTML][HTML] A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms

D Ménard, N Khim, J Beghain… - … England Journal of …, 2016 - Mass Medical Soc
Background Recent gains in reducing the global burden of malaria are threatened by the
emergence of Plasmodium falciparum resistance to artemisinins. The discovery that …

Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem

SJ Rogerson, M Desai, A Mayor, E Sicuri… - The Lancet infectious …, 2018 - thelancet.com
Over the past 10 years, knowledge of the burden, economic costs, and consequences of
malaria in pregnancy has improved, and the prevalence of malaria caused by Plasmodium …

Artemisinin action and resistance in Plasmodium falciparum

L Tilley, J Straimer, NF Gnädig, SA Ralph… - Trends in …, 2016 - cell.com
The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …

Advances and opportunities in malaria population genomics

DE Neafsey, AR Taylor, BL MacInnis - Nature Reviews Genetics, 2021 - nature.com
Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …

Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa

PJ Rosenthal, V Asua, MD Conrad - Nature Reviews Microbiology, 2024 - nature.com
Malaria, mostly due to Plasmodium falciparum infection in Africa, remains one of the most
important infectious diseases in the world. Standard treatment for uncomplicated P …

[HTML][HTML] Antimalarial drug resistance: literature review and activities and findings of the ICEMR network

L Cui, S Mharakurwa, D Ndiaye… - The American journal …, 2015 - ncbi.nlm.nih.gov
Antimalarial drugs are key tools for the control and elimination of malaria. Recent decreases
in the global malaria burden are likely due, in part, to the deployment of artemisinin-based …

[HTML][HTML] Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker

KM Tun, M Imwong, KM Lwin, AA Win… - The Lancet infectious …, 2015 - thelancet.com
Background Emergence of artemisinin resistance in southeast Asia poses a serious threat to
the global control of Plasmodium falciparum malaria. Discovery of the K13 marker has …