Reporting and interpreting decision curve analysis: a guide for investigators
Context Urologists regularly develop clinical risk prediction models to support clinical
decisions. In contrast to traditional performance measures, decision curve analysis (DCA) …
decisions. In contrast to traditional performance measures, decision curve analysis (DCA) …
Developing and evaluating polygenic risk prediction models for stratified disease prevention
Abstract Knowledge of genetics and its implications for human health is rapidly evolving in
accordance with recent events, such as discoveries of large numbers of disease …
accordance with recent events, such as discoveries of large numbers of disease …
New insights into the genetic etiology of Alzheimer's disease and related dementias
Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
Genome-wide meta-analysis identifies 93 risk loci and enables risk prediction equivalent to monogenic forms of venous thromboembolism
We report a genome-wide association study of venous thromboembolism (VTE)
incorporating 81,190 cases and 1,419,671 controls sampled from six cohorts. We identify 93 …
incorporating 81,190 cases and 1,419,671 controls sampled from six cohorts. We identify 93 …
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
Prostate cancer is a highly heritable disease with large disparities in incidence rates across
ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer …
ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer …
An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci
Genome-wide association studies (GWASs) have identified many variants associated with
complex traits, but identifying the causal gene (s) is a major challenge. In the present study …
complex traits, but identifying the causal gene (s) is a major challenge. In the present study …
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
The transferability and clinical value of genetic risk scores (GRSs) across populations
remain limited due to an imbalance in genetic studies across ancestrally diverse …
remain limited due to an imbalance in genetic studies across ancestrally diverse …
PROBAST: a tool to assess risk of bias and applicability of prediction model studies: explanation and elaboration
KGM Moons, RF Wolff, RD Riley, PF Whiting… - Annals of internal …, 2019 - acpjournals.org
Prediction models in health care use predictors to estimate for an individual the probability
that a condition or disease is already present (diagnostic model) or will occur in the future …
that a condition or disease is already present (diagnostic model) or will occur in the future …
Genetic markers of type 2 diabetes: Progress in genome‐wide association studies and clinical application for risk prediction: 2 型糖尿病的遗传标记: 风险预测的全 …
X Wang, G Strizich, Y Hu, T Wang… - Journal of …, 2016 - Wiley Online Library
摘要2 型糖尿病已经成为全球公共卫生的主要挑战. 迄今为止, 通过全基因组关联研究(genome‐
wide association studies, GWAS) 总共已经鉴定出了83 个2 型糖尿病易感位点. 为了发现2 …
wide association studies, GWAS) 总共已经鉴定出了83 个2 型糖尿病易感位点. 为了发现2 …
A nomogram for predicting overall survival in patients with low‐grade endometrial stromal sarcoma: a population‐based analysis
J Wu, H Zhang, L Li, M Hu, L Chen, B Xu… - Cancer …, 2020 - Wiley Online Library
Background Low‐grade endometrial stromal sarcoma (LG‐ESS) is a rare tumor that lacks a
prognostic prediction model. Our study aimed to develop a nomogram to predict overall …
prognostic prediction model. Our study aimed to develop a nomogram to predict overall …