Capsaicin, the pungent ingredient of the hot chili pepper, is known to act on the transient
receptor potential cation channel vanilloid subfamily member 1 (TRPV1). TRPV1 is involved …

Approximately 20 of the 30 mammalian transient receptor potential (TRP) channel subunits
are expressed by specific neurons and cells within the alimentary canal. They subserve …

Background Despite gastro‐esophageal reflux disease affecting up to 20% of Western
populations, relatively little is known about the molecular mechanisms underlying its most …

Gastroesophageal reflux disease (GERD) is one of the most common problems in clinical
practice today. It is widely believed that functional and structural abnormalities of the …

Objective Patients with non-erosive reflux disease (NERD) have impaired oesophageal
mucosal integrity (dilated intercellular spaces). Oesophageal mucosal integrity reflects the …

Background Transient receptor potential channel vanilloid subfamily member‐1 (TRPV1)
may play a role in esophageal perception. TRPV1 mRNA and protein expression were …

Several of the 28 mammalian transient receptor potential (TRP) channel subunits are
expressed throughout the alimentary canal where they play important roles in taste, chemo …

Dysfunction in the esophageal epithelial barrier function is a major source for morbidity. To
better understand the pathophysiologic pathways of the diseases associated with barrier …

The members of the superfamily of transient receptor potential (TRP) cation channels are
involved in a plethora of cellular functions. During the last decade, a vast amount of …

Gastroesophageal reflux disease (GERD) affects 20–30% of the population in Western
countries, and is one of the most common clinical problems in daily practice. GERD …