The urothelium, which lines the renal pelvis, ureters, urinary bladder, and proximal urethra,
forms a high-resistance but adaptable barrier that surveils its mechanochemical …

The evolutionarily conserved endosomal retromer complex rescues transmembrane
proteins from the lysosomal degradative pathway and facilitates their recycling to other …

Following endocytosis into the endosomal network, integral membrane proteins undergo
sorting for lysosomal degradation or are retrieved and recycled back to the cell surface. Here …

Familial exudative vitreoretinopathy (FEVR) is a complex hereditary eye disorder
characterized by incomplete development of the retinal vasculature, which thereby affects …

Automatic segmentation of intracellular compartments is a powerful technique, which
provides quantitative data about presence, spatial distribution, structure and consequently …

The sorting nexin (SNX) family consists of a diverse group of cytoplasmic-and membrane-
associated phosphoinositide-binding proteins that play pivotal roles in the regulation of …

Sorting of macromolecules within the endosomal system is vital for physiological control of
nutrient homeostasis, cell motility, and proteostasis. Trafficking routes that export …

Endocytosis is a fundamental process that controls protein/lipid composition of the plasma
membrane, thereby shaping cellular metabolism, sensing, adhesion, signaling, and nutrient …

Recently, we showed that HIV-1 is sequestered, ie, trapped, in the intracellular vesicles of
oral and genital epithelial cells. Here, we investigated the mechanisms of HIV-1 …

Ketamine is a popular choice for young drug abusers. Ketamine abuse causes lower urinary
tract symptoms, with the underlying pathophysiology poorly understood. Disruption of …