Prefrontal-hippocampal interactions supporting the extinction of emotional memories: the retrieval stopping model
MC Anderson, SB Floresco - Neuropsychopharmacology, 2022 - nature.com
Neuroimaging has revealed robust interactions between the prefrontal cortex and the
hippocampus when people stop memory retrieval. Efforts to stop retrieval can arise when …
hippocampus when people stop memory retrieval. Efforts to stop retrieval can arise when …
Event-based control of autonomic and emotional states by the anterior cingulate cortex
JK Seamans, SB Floresco - Neuroscience & Biobehavioral Reviews, 2022 - Elsevier
Despite being an intensive area of research, the function of the anterior cingulate cortex
(ACC) remains somewhat of a mystery. Human imaging studies implicate the ACC in various …
(ACC) remains somewhat of a mystery. Human imaging studies implicate the ACC in various …
Sex-biased neural encoding of threat discrimination in nucleus accumbens afferents drives suppression of reward behavior
Learning to predict threat is essential, but equally important—yet often overlooked—is
learning about the absence of threat. Here, by recording neural activity in two nucleus …
learning about the absence of threat. Here, by recording neural activity in two nucleus …
Distinct medial orbitofrontal–striatal circuits support dissociable component processes of risk/reward decision-making
NL Jenni, G Rutledge, SB Floresco - Journal of Neuroscience, 2022 - Soc Neuroscience
The medial orbitofrontal cortex (mOFC) regulates a variety of cognitive functions, including
refining action selection involving reward uncertainty. This region sends projections to …
refining action selection involving reward uncertainty. This region sends projections to …
[HTML][HTML] Sex and age differences in cognitive bias and neural activation in response to cognitive bias testing
Cognitive symptoms of depression, including negative cognitive bias, are more severe in
women than in men. Current treatments to reduce negative cognitive bias are not effective …
women than in men. Current treatments to reduce negative cognitive bias are not effective …
Brain-wide projections and differential encoding of prefrontal neuronal classes underlying learned and innate threat avoidance
To understand how the brain produces behavior, we must elucidate the relationships
between neuronal connectivity and function. The medial prefrontal cortex (mPFC) is critical …
between neuronal connectivity and function. The medial prefrontal cortex (mPFC) is critical …
Neural correlates and determinants of approach–avoidance conflict in the prelimbic prefrontal cortex
JA Fernandez-Leon, DS Engelke, G Aquino-Miranda… - Elife, 2021 - elifesciences.org
The recollection of environmental cues associated with threat or reward allows animals to
select the most appropriate behavioral responses. Neurons in the prelimbic (PL) cortex …
select the most appropriate behavioral responses. Neurons in the prelimbic (PL) cortex …
Medial prefrontal cortical control of reward‐and aversion‐based behavioral output: Bottom‐up modulation
How does the brain guide our actions? This is a complex issue, where the medial prefrontal
cortex (mPFC) plays a crucial role. The mPFC is essential for cognitive flexibility and …
cortex (mPFC) plays a crucial role. The mPFC is essential for cognitive flexibility and …
[HTML][HTML] Dissociable roles of the nucleus accumbens core and shell subregions in the expression and extinction of conditioned fear
The nucleus accumbens (NAc), consisting of core (NAcC) and shell (NAcS) sub-regions, has
primarily been studied as a locus mediating the effects of drug reward and addiction …
primarily been studied as a locus mediating the effects of drug reward and addiction …
Threat and bidirectional valence signaling in the nucleus accumbens core
Appropriate responding to threat and reward is essential to survival. The nucleus
accumbens core (NAcc) is known to support and organize reward behavior. The NAcc is …
accumbens core (NAcc) is known to support and organize reward behavior. The NAcc is …