Diversity and biology of cancer-associated fibroblasts
G Biffi, DA Tuveson - Physiological reviews, 2020 - journals.physiology.org
Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial
compartment, despite the presence of non-neoplastic stromal components that substantially …
compartment, despite the presence of non-neoplastic stromal components that substantially …
The pancreatic cancer genome revisited
A Hayashi, J Hong… - … reviews Gastroenterology & …, 2021 - nature.com
Pancreatic cancer is a genetic disease, and the recurrent genetic alterations characteristic of
pancreatic cancer indicate the cellular processes that are targeted for malignant …
pancreatic cancer indicate the cellular processes that are targeted for malignant …
[HTML][HTML] Spatially confined sub-tumor microenvironments in pancreatic cancer
Intratumoral heterogeneity is a critical frontier in understanding how the tumor
microenvironment (TME) propels malignant progression. Here, we deconvolute the human …
microenvironment (TME) propels malignant progression. Here, we deconvolute the human …
Inhibition of hedgehog signaling alters fibroblast composition in pancreatic cancer
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease characterized by
an extensive fibroinflammatory stroma, which includes abundant cancer-associated …
an extensive fibroinflammatory stroma, which includes abundant cancer-associated …
Cell-autonomous Cxcl1 sustains tolerogenic circuitries and stromal inflammation via neutrophil-derived TNF in pancreatic cancer
We have shown that KRAS–TP53 genomic coalteration is associated with immune-excluded
microenvironments, chemoresistance, and poor survival in pancreatic ductal …
microenvironments, chemoresistance, and poor survival in pancreatic ductal …
The transcriptional and epigenetic landscape of cancer cell lineage plasticity
Lineage plasticity, a process whereby cells change their phenotype to take on a different
molecular and/or histologic identity, is a key driver of cancer progression and therapy …
molecular and/or histologic identity, is a key driver of cancer progression and therapy …
Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis
Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with a complex
microenvironment. Dichotomous tumour-promoting and-restrictive roles have been ascribed …
microenvironment. Dichotomous tumour-promoting and-restrictive roles have been ascribed …
Combined MEK and STAT3 inhibition uncovers stromal plasticity by enriching for cancer-associated fibroblasts with mesenchymal stem cell-like features to overcome …
Background & Aims We have shown that reciprocally activated rat sarcoma (RAS)/mitogen-
activated protein kinase/extracellular signal-regulated kinase (MEK) and Janus …
activated protein kinase/extracellular signal-regulated kinase (MEK) and Janus …
TNF-α-producing macrophages determine subtype identity and prognosis via AP1 enhancer reprogramming in pancreatic cancer
M Tu, L Klein, E Espinet, T Georgomanolis, F Wegwitz… - Nature cancer, 2021 - nature.com
Large-scale genomic profiling of pancreatic cancer (PDAC) has revealed two distinct
subtypes:'classical'and 'basal-like'. Their variable coexistence within the stromal immune …
subtypes:'classical'and 'basal-like'. Their variable coexistence within the stromal immune …
CXCL1: Gene, Promoter, Regulation of Expression, mRNA Stability, Regulation of Activity in the Intercellular Space
J Korbecki, K Barczak, I Gutowska, D Chlubek… - International journal of …, 2022 - mdpi.com
CXCL1 is one of the most important chemokines, part of a group of chemotactic cytokines
involved in the development of many inflammatory diseases. It activates CXCR2 and, at high …
involved in the development of many inflammatory diseases. It activates CXCR2 and, at high …