Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

The development, maintenance of healthy bone and regeneration of injured tissue in the
human body comprise a set of intricate and finely coordinated processes. However, an …

Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease
modeling and have unlocked new possibilities for understanding the mechanisms governing …

The rising incidence of bone disorders has resulted in the need for more effective therapies
to meet this demand, exacerbated by an increasing ageing population. Bone tissue …

Bone is a highly vascularized tissue, and its development, maturation, remodeling, and
regeneration are dependent on a tight regulation of blood vessel supply. This condition also …

The reconstruction of musculoskeletal defects is a constant challenge for orthopaedic
surgeons. Musculoskeletal injuries such as fractures, chondral lesions, infections and tumor …

Facial deformities require precise reconstruction of the appearance and function of the
original tissue. The current standard of care—the use of bone harvested from another region …

The extracellular matrix is produced by the resident cells in tissues and organs, and
secreted into the surrounding medium to provide biophysical and biochemical support to the …

The high brittleness and low strength of bioactive ceramics have severely restricted their
application in bone repair despite the fact that they have been regarded as one of the most …

Organ transplantation is an effective treatment for chronic organ dysfunctioning conditions.
However, a dearth of available donor organs for transplantation leads to the death of …