Alzheimer's disease

JAS Lopez, HM González, GC Léger - Handbook of clinical neurology, 2019 - Elsevier
Alzheimer's disease (AD) dementia refers to a particular onset and course of cognitive and
functional decline associated with age together with a particular neuropathology. It was first …

The neuropathology of chronic traumatic encephalopathy

AC McKee, TD Stein, PT Kiernan, VE Alvarez - Brain pathology, 2015 - Wiley Online Library
Repetitive brain trauma is associated with a progressive neurological deterioration, now
termed as chronic traumatic encephalopathy (CTE). Most instances of CTE occur in …

Clinicopathological evaluation of chronic traumatic encephalopathy in players of American football

J Mez, DH Daneshvar, PT Kiernan… - Jama, 2017 - jamanetwork.com
Importance Players of American football may be at increased risk of long-term neurological
conditions, particularly chronic traumatic encephalopathy (CTE). Objective To determine the …

A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research

PL De Jager, Y Ma, C McCabe, J Xu, BN Vardarajan… - Scientific data, 2018 - nature.com
We initiated the systematic profiling of the dorsolateral prefrontal cortex obtained from a
subset of autopsied individuals enrolled in the Religious Orders Study (ROS) or the Rush …

The spectrum of disease in chronic traumatic encephalopathy

AC McKee, TD Stein, CJ Nowinski, RA Stern… - Brain, 2013 - academic.oup.com
Chronic traumatic encephalopathy is a progressive tauopathy that occurs as a consequence
of repetitive mild traumatic brain injury. We analysed post-mortem brains obtained from a …

Accuracy of the clinical diagnosis of Alzheimer disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010

TG Beach, SE Monsell, LE Phillips… - … of neuropathology and …, 2012 - academic.oup.com
The neuropathologic examination is considered to provide the gold standard for Alzheimer
disease (AD). To determine the accuracy of currently used clinical diagnostic methods …

[HTML][HTML] Synapse pathology in Alzheimer's disease

J Griffiths, SGN Grant - Seminars in Cell & Developmental Biology, 2023 - Elsevier
Synapse loss and damage are central features of Alzheimer's disease (AD) and contribute to
the onset and progression of its behavioural and physiological features. Here we review the …

Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation

S Villeneuve, GD Rabinovici, BI Cohn-Sheehy… - Brain, 2015 - academic.oup.com
Amyloid-β, a hallmark of Alzheimer's disease, begins accumulating up to two decades
before the onset of dementia, and can be detected in vivo applying amyloid-β positron …

Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides …

CC Willhite, NA Karyakina, RA Yokel… - Critical reviews in …, 2014 - Taylor & Francis
Aluminum (Al) is a ubiquitous substance encountered both naturally (as the third most
abundant element) and intentionally (used in water, foods, pharmaceuticals, and vaccines); …

Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry

H Braak, I Alafuzoff, T Arzberger, H Kretzschmar… - Acta …, 2006 - Springer
Assessment of Alzheimer's disease (AD)-related neurofibrillary pathology requires a
procedure that permits a sufficient differentiation between initial, intermediate, and late …