Cancer cells frequently harbor defects in DNA repair pathways, leading to genomic
instability. This can foster tumorigenesis but also provides a weakness in the tumor that can …

Germline mutations in BRCA1 and BRCA2 predispose to common human malignancies,
most notably tumors of the breast and ovaries. The proteins encoded by these genes have …

The underlying mechanism behind age-induced wastage of the human ovarian follicle
reserve is unknown. We identify impaired ATM (ataxia-telangiectasia mutated)–mediated …

Purpose Olaparib (AZD2281), an orally active poly (ADP-ribose) polymerase inhibitor that
induces synthetic lethality in BRCA1-or BRCA2-deficient cells, has shown promising clinical …

The distinction between malignant mesothelioma and reactive mesothelial proliferation can
be challenging both on histology and cytology. Recently, variants of the BRCA1-associated …

Germline mutations in BRCA1 confer a high risk of breast and ovarian tumors. The role of
BRCA1 in tumor suppression is not yet understood, but both transcription and repair …

The BRCA2 tumor suppressor has been implicated in the maintenance of chromosomal
stability through a function in DNA repair. In this report, we examine human and mouse cell …

In lower eukaryotes, Sir2 serves as a histone deacetylase and is implicated in chromatin
silencing, longevity, and genome stability. Here we mutated the Sirt1 gene, a homolog of …

Immune checkpoint blockade (ICB) is a powerful approach for cancer therapy although good
responses are only observed in a fraction of cancer patients. Breast cancers caused by …

DNA damage response genes play vital roles in the maintenance of a healthy genome.
Defects in cell cycle checkpoint and DNA repair genes, especially mutation or aberrant …