Involvement of Astrocytes in the Formation, Maintenance, and Function of the Blood–Brain Barrier
G Schiera, CM Di Liegro, G Schirò, G Sorbello… - Cells, 2024 - mdpi.com
The blood–brain barrier (BBB) is a fundamental structure that protects the composition of the
brain by determining which ions, metabolites, and nutrients are allowed to enter the brain …
brain by determining which ions, metabolites, and nutrients are allowed to enter the brain …
Complex in vitro models positioned for impact to drug testing in pharma: a review
S Kang, EC Chen, H Cifuentes, G Cole, J Graham… - …, 2024 - iopscience.iop.org
Recent years have seen the creation and popularization of various complex in vitro models
(CIVMs), such as organoids and organs-on-chip, as a technology with the potential to …
(CIVMs), such as organoids and organs-on-chip, as a technology with the potential to …
Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic …
Alzheimer's disease (AD) is the most common neurodegenerative disorder and one of the
leading causes of disability worldwide. The apolipoprotein E4 gene (APOE4) is the strongest …
leading causes of disability worldwide. The apolipoprotein E4 gene (APOE4) is the strongest …
Induced pluripotent stem cell derived pericytes respond to mediators of proliferation and contractility
Background Pericytes are multifunctional contractile cells that reside on capillaries.
Pericytes are critical regulators of cerebral blood flow and blood–brain barrier function, and …
Pericytes are critical regulators of cerebral blood flow and blood–brain barrier function, and …
Generation of hiPSC-derived brain microvascular endothelial cells using a combination of directed differentiation and transcriptional reprogramming strategies
A Cui, R Patel, P Bosco, U Akcan, E Richters… - bioRxiv, 2024 - biorxiv.org
The blood-brain barrier (BBB), formed by specialized brain microvascular endothelial cells
(BMECs), regulates brain function in health and disease. In vitro modeling of the human BBB …
(BMECs), regulates brain function in health and disease. In vitro modeling of the human BBB …