Pharmacotherapy for neuropsychiatric disorders, such as anxiety and depression, has been characterized by significant inter-individual variability in drug response and the development …
JMJL Brouwer, M Nijenhuis, B Soree… - European Journal of …, 2022 - nature.com
Abstract The Dutch Pharmacogenetics Working Group (DPWG) guideline presented here, presents the gene-drug interaction between the genes CYP2C19 and CYP2D6 and …
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly used psychopharmaceutical treatment for major depressive disorder (MDD), but individual …
K Kleine Schaars, R van Westrhenen - Journal of Personalized Medicine, 2023 - mdpi.com
Due to the chronic relapsing nature of mental disorders and increased life expectancy, the societal burden of these non-communicable diseases will increase even further. Treatments …
E de Brabander, KK Schaars, T van Amelsvoort… - Journal of Psychiatric …, 2024 - Elsevier
Variability in hepatic cytochrome P450 (CYP) enzymes such as 2C19 and 2D6 may influence side-effect and efficacy outcomes for antipsychotics. Aripiprazole and risperidone …
B Roberts, Z Cooper, S Lu, S Stanley… - Frontiers in …, 2023 - frontiersin.org
Pharmacogenetics (PGx) is the study and application of how interindividual differences in our genomes can influence drug responses. By evaluating individuals' genetic variability in …
(1) Background Pharmacological treatment for psychiatric disorders has shown to only be effective in about one-third of patients, as it is associated with frequent treatment failure …
A Jameson, M Faisal, B Fylan… - Journal of …, 2024 - journals.sagepub.com
Background: Prescribing drugs for psychosis (antipsychotics) is challenging due to high rates of poor treatment outcomes, which are in part explained by an individual's genetics …
JR O'Neill, A Jameson, SL McLean… - Journal of …, 2024 - journals.sagepub.com
Background: Presently, there is limited guidance on the maximal dosing of psychosis drugs that is based on effectiveness rather than safety or toxicity. Current maximum dosing …