The shared role of amyloid-β (Aβ) deposition in cerebral amyloid angiopathy (CAA) and
Alzheimer disease (AD) is arguably the clearest instance of crosstalk between …

The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …

There is significant evidence that, in living systems, free radicals and other reactive oxygen
and nitrogen species play a double role, because they can cause oxidative damage and …

Background Microglia, the brain's principal immune cell, are increasingly implicated in
Alzheimer's disease (AD), but the molecular interfaces through which these cells contribute …

Autosomal-dominant Alzheimer's disease has provided significant understanding of the
pathophysiology of Alzheimer's disease. The present review summarizes clinical …

Alzheimer's disease (AD) is characterized neuropathologically by neuronal cell loss,
extracellular neuritic plaques composed of β-amyloid (Aβ), and intracellular neurofibrillary …

Alzheimer's disease (AD) is a complex and heterogeneous neurodegenerative disorder,
classified as either early onset (under 65 years of age), or late onset (over 65 years of age) …

The hallmarks of Alzheimer's disease (AD) are the accumulation of Aβ plaques and
neurofibrillary tangles composed of hyperphosphorylated tau. We developed sensitive …

Here we review the genetic causes and risks for Alzheimer's disease (AD). Early work
identified mutations in three genes that cause AD: APP, PSEN1 and PSEN2. Although …

The brain pathology of Alzheimer's disease is characterized by abnormally aggregated Aβ in
extracellular β-amyloid plaques and along blood vessel walls, but the relation to intracellular …