Modelling cancer in microfluidic human organs-on-chips
A Sontheimer-Phelps, BA Hassell, DE Ingber - Nature Reviews Cancer, 2019 - nature.com
One of the problems that has slowed the development and approval of new anticancer
therapies is the lack of preclinical models that can be used to identify key molecular, cellular …
therapies is the lack of preclinical models that can be used to identify key molecular, cellular …
In Vitro Tumor Models: Advantages, Disadvantages, Variables, and Selecting the Right Platform
In vitro tumor models have provided important tools for cancer research and serve as low-
cost screening platforms for drug therapies; however, cancer recurrence remains largely …
cost screening platforms for drug therapies; however, cancer recurrence remains largely …
Microfluidic organs-on-chips
An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing
methods that contains continuously perfused chambers inhabited by living cells arranged to …
methods that contains continuously perfused chambers inhabited by living cells arranged to …
Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation
A key aspect of cancer metastases is the tendency for specific cancer cells to home to
defined subsets of secondary organs. Despite these known tendencies, the underlying …
defined subsets of secondary organs. Despite these known tendencies, the underlying …
On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics
Distant metastasis, which results in> 90% of cancer-related deaths, is enabled by
hematogenous dissemination of tumor cells via the circulation. This requires the completion …
hematogenous dissemination of tumor cells via the circulation. This requires the completion …
Crossing the endothelial barrier during metastasis
N Reymond, BB d'Água, AJ Ridley - Nature Reviews Cancer, 2013 - nature.com
During metastasis, cancer cells disseminate to other parts of the body by entering the
bloodstream in a process that is called intravasation. They then extravasate at metastatic …
bloodstream in a process that is called intravasation. They then extravasate at metastatic …
[HTML][HTML] Microfluidic 3D cell culture: from tools to tissue models
Highlights•Comprehensive review of advances in microfluidic 3D cell culture since
2012.•Increased physiological relevance by precise control of cellular microenvironment.• …
2012.•Increased physiological relevance by precise control of cellular microenvironment.• …
Review of collagen I hydrogels for bioengineered tissue microenvironments: characterization of mechanics, structure, and transport
EE Antoine, PP Vlachos… - Tissue Engineering Part B …, 2014 - liebertpub.com
Type I collagen hydrogels have been used successfully as three-dimensional substrates for
cell culture and have shown promise as scaffolds for engineered tissues and tumors. A …
cell culture and have shown promise as scaffolds for engineered tissues and tumors. A …
A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone
Cancer metastases arise following extravasation of circulating tumor cells with certain
tumors exhibiting high organ specificity. Here, we developed a 3D microfluidic model to …
tumors exhibiting high organ specificity. Here, we developed a 3D microfluidic model to …
Tumor spheroid-on-a-chip: a standardized microfluidic culture platform for investigating tumor angiogenesis
The field of microfluidics-based three-dimensional (3D) cell culture system is rapidly
progressing from academic proof-of-concept studies to valid solutions to real-world …
progressing from academic proof-of-concept studies to valid solutions to real-world …