Abstract Interleukin-33 (IL-33), a member of the IL-1 family, is an alarmin cytokine with
crucial roles in tissue homeostasis and repair, type 2 immunity, allergic and non-allergic …

Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from
anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag …

Summary Interleukin‐33 (IL‐33) is a tissue‐derived nuclear cytokine from the IL‐1 family
abundantly expressed in endothelial cells, epithelial cells and fibroblast‐like cells, both …

Abstract Interleukin-33 (IL-33)—a member of the IL-1 family—was originally described as an
inducer of type 2 immune responses, activating T helper 2 (TH2) cells and mast cells. Now …

Research over the last 7 years has led to the formal identification of innate lymphoid cells
(ILCs), increased the understanding of their tissue distribution and has established essential …

The innate immune system is composed of a diverse array of evolutionarily ancient
haematopoietic cell types, including dendritic cells, monocytes, macrophages and …

Asthma is a common disease that affects 300 million people worldwide. Given the large
number of eosinophils in the airways of people with mild asthma, and verified by data from …

Helminth parasite infections are associated with a battery of immunomodulatory
mechanisms that affect all facets of the host immune response to ensure their persistence …

Interleukin-1 (IL-1) family cytokines are key signaling molecules in both the innate and
adaptive immune systems, mediating inflammation in response to a wide range of stimuli …

Highlights•IL-33 is a crucial activator of ILC2s in innate immunity and allergic
inflammation.•The gene encoding IL-33 is a major susceptibility locus for human asthma.•IL …