The roles of serotonin in neuropsychiatric disorders
The serotonergic system extends throughout the central nervous system (CNS) and the
gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a …
gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a …
[HTML][HTML] Neurobiology and consequences of social isolation stress in animal model—A comprehensive review
The brain is a vital organ, susceptible to alterations under genetic influences and
environmental experiences. Social isolation (SI) acts as a stressor which results in …
environmental experiences. Social isolation (SI) acts as a stressor which results in …
Rewiring of the serotonin system in major depression
F Vahid-Ansari, PR Albert - Frontiers in psychiatry, 2021 - frontiersin.org
Serotonin is a key neurotransmitter that is implicated in a wide variety of behavioral and
cognitive phenotypes. Originating in the raphe nuclei, 5-HT neurons project widely to …
cognitive phenotypes. Originating in the raphe nuclei, 5-HT neurons project widely to …
Structural basis for partial agonism in 5-HT3A receptors
K Felt, M Stauffer, L Salas-Estrada, PR Guzzo… - Nature Structural & …, 2024 - nature.com
Abstract Hyperactivity of serotonin 3 receptors (5-HT3R) underlies pathologies associated
with irritable bowel syndrome and chemotherapy-induced nausea and vomiting. Setrons, a …
with irritable bowel syndrome and chemotherapy-induced nausea and vomiting. Setrons, a …
How serotonin receptors regulate morphogenic signalling in neurons
A Wirth, K Holst, E Ponimaskin - Progress in neurobiology, 2017 - Elsevier
Abstract Serotonin (5-hydroxytrympamine or 5-HT) is one of the phylogenetically oldest
neurotransmitters, and the serotonergic system is among the earliest developed neuronal …
neurotransmitters, and the serotonergic system is among the earliest developed neuronal …
Cryo-EM structure of 5-HT3A receptor in its resting conformation
Abstract Serotonin receptors (5-HT3AR) directly regulate gut movement, and drugs that
inhibit 5-HT3AR function are used to control emetic reflexes associated with gastrointestinal …
inhibit 5-HT3AR function are used to control emetic reflexes associated with gastrointestinal …
Does serotonin deficit mediate susceptibility to ADHD?
E Banerjee, K Nandagopal - Neurochemistry international, 2015 - Elsevier
The onset of attention-deficit-hyperactivity-disorder (ADHD) in childhood is characterized by
developmentally inappropriate levels of hyperactivity, impulsivity and inattention. A chronic …
developmentally inappropriate levels of hyperactivity, impulsivity and inattention. A chronic …
Lipid raft facilitated receptor organization and signaling: a functional rheostat in embryonic development, stem cell biology and cancer
A Roy, SK Patra - Stem cell reviews and reports, 2023 - Springer
Molecular views of plasma membrane organization and dynamics are gradually changing
over the past fifty years. Dynamics of plasma membrane instigate several signaling nexuses …
over the past fifty years. Dynamics of plasma membrane instigate several signaling nexuses …
Cellular and molecular targets of menthol actions
M Oz, EG El Nebrisi, KHS Yang, FC Howarth… - Frontiers in …, 2017 - frontiersin.org
Menthol belongs to monoterpene class of a structurally diverse group of phytochemicals
found in plant-derived essential oils. Menthol is widely used in pharmaceuticals …
found in plant-derived essential oils. Menthol is widely used in pharmaceuticals …
Crosstalk between intestinal serotonergic system and pattern recognition receptors on the microbiota–gut–brain axis
E Layunta, B Buey, JE Mesonero… - Frontiers in …, 2021 - frontiersin.org
Disruption of the microbiota–gut–brain axis results in a wide range of pathologies that are
affected, from the brain to the intestine. Gut hormones released by enteroendocrine cells to …
affected, from the brain to the intestine. Gut hormones released by enteroendocrine cells to …