JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications

V Kasinath, C Beck, P Sauer, S Poepsel, J Kosmatka… - Science, 2021 - science.org
INTRODUCTION Histone modification activity of the polycomb repressive complexes 1 and
2 (PRC1 and PRC2) is critical for the establishment and maintenance of gene expression …

H2B Lys34 ubiquitination induces nucleosome distortion to stimulate Dot1L activity

H Ai, M Sun, A Liu, Z Sun, T Liu, L Cao, L Liang… - Nature Chemical …, 2022 - nature.com
Ubiquitination-dependent histone crosstalk plays critical roles in chromatin-associated
processes and is highly associated with human diseases. Mechanism studies of the …

A mechanism for the suppression of homologous recombination in G1 cells

A Orthwein, SM Noordermeer, MD Wilson, S Landry… - Nature, 2015 - nature.com
DNA repair by homologous recombination is highly suppressed in G1 cells, to ensure that
mitotic recombination occurs solely between sister chromatids. Although many homologous …

Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2

S Cooper, A Grijzenhout, E Underwood… - Nature …, 2016 - nature.com
The Polycomb repressive complexes PRC1 and PRC2 play a central role in developmental
gene regulation in multicellular organisms. PRC1 and PRC2 modify chromatin by catalysing …

BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination

JR Becker, G Clifford, C Bonnet, A Groth, MD Wilson… - Nature, 2021 - nature.com
Protein ubiquitination at sites of DNA double-strand breaks (DSBs) by RNF168 recruits
BRCA1 and 53BP1,, which are mediators of the homologous recombination and non …

Regulation of the Dot1 histone H3K79 methyltransferase by histone H4K16 acetylation

MI Valencia-Sánchez, P De Ioannes, M Wang… - Science, 2021 - science.org
INTRODUCTION Nucleosomes—the primary, repeating unit of chromatin—package and
protect the genome while also transmitting various regulatory signals through, in part …

The structural basis of modified nucleosome recognition by 53BP1

MD Wilson, S Benlekbir, A Fradet-Turcotte, A Sherker… - Nature, 2016 - nature.com
DNA double-strand breaks (DSBs) elicit a histone modification cascade that controls DNA
repair,,. This pathway involves the sequential ubiquitination of histones H1 and H2A by the …

DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation

W Ren, H Fan, SA Grimm, JJ Kim, L Li, Y Guo… - Nature …, 2021 - nature.com
DNA methylation and trimethylated histone H4 Lysine 20 (H4K20me3) constitute two
important heterochromatin-enriched marks that frequently cooperate in silencing repetitive …

Structural basis of Dot1L stimulation by histone H2B lysine 120 ubiquitination

MI Valencia-Sánchez, P De Ioannes, M Wang… - Molecular cell, 2019 - cell.com
The essential histone H3 lysine 79 methyltransferase Dot1L regulates transcription and
genomic stability and is deregulated in leukemia. The activity of Dot1L is stimulated by mono …

Posttranslational chemical mutagenesis methods to insert posttranslational modifications into recombinant proteins

O Harel, M Jbara - Molecules, 2022 - mdpi.com
Posttranslational modifications (PTMs) dramatically expand the functional diversity of the
proteome. The precise addition and removal of PTMs appears to modulate protein structure …