Challenges and progress in nonsteroidal anti-inflammatory drugs co-crystal development

I Nugrahani, RD Parwati - Molecules, 2021 - mdpi.com
Co-crystal innovation is an opportunity in drug development for both scientists and industry.
In line with the “green pharmacy” concept for obtaining safer methods and advanced …

Pharmaceutical salts of piroxicam and meloxicam with organic counterions

S Huang, DS Venables, SE Lawrence - Crystal growth & design, 2022 - ACS Publications
Piroxicam (PRM) and meloxicam (MEL) are two nonsteroidal anti-inflammatory drugs,
belonging to the Biopharmaceutics Classification System Class II drugs. In this study, six …

Formulation development and evaluation of microemulsion based lornoxicam gel

NA Thombre, PS Niphade, ED Ahire… - Biosciences …, 2022 - biotech-asia.org
The objective of the existing research was formulation development and preparation of
microemulsion loaded emulgel in augmenting the topical delivery of Lornoxicam. Emulsion …

[HTML][HTML] Improved solubility of lornoxicam by inclusion into SBA-15: Comparison of loading methods

A Dadej, A Woźniak-Braszak, P Bilski… - European Journal of …, 2022 - Elsevier
An increasing proportion of new medicinal substances are poorly soluble in water.
Adsorption on mesoporous silicas increases their bioavailability when administered orally …

Amelioration of physicochemical, pharmaceutical, and pharmacokinetic properties of lornoxicam by cocrystallization with a novel coformer

K Fatima, NI Bukhari, S Latif, H Afzal… - Drug Development …, 2021 - Taylor & Francis
Objective The present study was aimed to prepare and characterize new cocrystals of
lornoxicam (LORX), a BCS class II drug employing 1, 3-dimethyl urea (DMU) as a coformer …

[PDF][PDF] Study the effect of wet granulation and fusion methods on preparation, characterization, and release of lornoxicam sachet effervescent granules

ZE Jassim, NA Rajab, NH Mohammed - Drug Invention Today, 2018 - researchgate.net
The present work is based on the formulation of effervescent granules of lornoxicam unit
dose. Six such formulations were prepared using citric and tartaric acids and sodium …

Desosomes and desimicelles− a novel vesicular and micellar system for enhanced oral delivery of poorly soluble drug: Optimization of in vitro characteristics and in …

AR Said, GF Asaad, ME Shabana, AS Sayed… - European Journal of …, 2024 - Elsevier
This study introduces two innovative nanocarrier systems to improve oral drug delivery.
Desosomes and desimicelles combine Deep eutectic solvent (DES) with vesicular or …

Development, optimization and pharmacokinetic evaluation of biphasic extended-release osmotic drug delivery system of trospium chloride for promising application …

R Gundu, S Pekamwar, S Shelke, D Kulkarni… - Future Journal of …, 2021 - Springer
Background The research was aimed with an approach to formulate biphasic extended-
release system of trospium chloride resulting in controlled release of drug up to 24 h with …

[PDF][PDF] Accidental formation of eutectics during crystal engineering of lamotrigine with solubility advantage and drug release efficiency

D Kulkarni - Asian Journal of Pharmaceutics (AJP), 2021 - asiapharmaceutics.info
Accidental Formation of Eutectics during Crystal Engineering of Lamotrigine with Solubility
Advantage and Drug Release Efficienc Page 1 Asian Journal of Pharmaceutics • Jan-Mar …

Intensified crystallization processes for 1: 1 drug–drug cocrystals of sulfathiazole–theophylline, and sulfathiazole–sulfanilamide

KL Yeh, T Lee - Crystal Growth & Design, 2018 - ACS Publications
The chemical synthesis and crystallization steps were integrated successfully for directly
producing a 1: 1 cocrystal of sulfathiazole–theophylline and a 1: 1 cocrystal of sulfathiazole …