Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels, the molecular
correlate of the hyperpolarization-activated current (If/Ih), are membrane proteins which play …

Discovered some 40 years ago, the I f current has since been known as the “pacemaker”
current due to its role in the initiation and modulation of the heartbeat and of neuronal …

There is an urgent need to develop approaches for repairing the damaged heart,
discovering new therapeutic drugs that do not have toxic effects on the heart, and improving …

Mitochondrial potassium channels control potassium influx into the mitochondrial matrix and
thus regulate mitochondrial membrane potential, volume, respiration, and synthesis of …

Lutein (β, ε-carotene-3, 3′-diol), a xanthophyll carotenoid, is found in high concentrations in
the macula of the human retina. It has been recognized to exert potential effectiveness in …

Hyperpolarized-activated cyclic nucleotide-gated (HCN) channels underlie
hyperpolarization-activated current (I h) and are involved in controlling the excitability and …

Hypertension is linked to hyperpolarization-activated cyclic nucleotide-gated (HCN) function,
expressed in excitable and non-excitable cells. Considering that the reduction in heart rate …

Current antipsychotic medications used to treat schizophrenia all target the dopamine D2
receptor. Although these drugs have serious side effects and limited efficacy, no novel …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels belong to the
superfamily of voltage-gated pore loop channels. In mammals, this family consists of four …

A geroscience-informed approach to the increasing prevalence of bladder control problems
in older adults requires understanding the impact of aging on dynamic mechanisms that …