Transition metal-catalysed C–H activation has emerged as an increasingly powerful platform
for molecular syntheses, enabling applications to natural product syntheses, late-stage …

In the field of C–H bond functionalization chemistry, directed C–H bond activation strategies
are highly appreciated due to the high efficiency and selectivity of such reactions towards a …

Conventional methods for carrying out carbon–hydrogen functionalization and carbon–
nitrogen bond formation are typically conducted at elevated temperatures, and rely on …

Conspectus Aromatic structures are widespread motifs throughout organic chemistry, and C–
H activation has been recognized as a major tool for enabling their sustainable and efficient …

The selective and efficient C–H methylation of sp2 and sp3 carbon centres has become a
powerful transformation in the synthetic toolbox. Due to the potential for profound changes to …

BACKGROUND Organic synthetic chemistry has facilitated the production of medicines,
agrochemicals, food, polymers, dyes, and more through step-and atom-economical …

Directing group assisted ortho‐C− H activation has been known for the last few decades. In
contrast, extending the same approach to achieve activation of the distal meta‐and para‐C …

Regioselective functionalization of arenes remains a challenging problem in organic
synthesis. Steric interactions are often used to block sites adjacent to a given substituent, but …

Olefinic C–H functionalization represents an atom-and step economic approach to valuable
olefin derivatives from simpler ones, but controlling the selectivity remains a challenge …

Cross-coupling reaction between two C–H bonds has become a fundamental strategy in
synthetic organic chemistry. With its increasing importance in green chemistry, atom …