Mast cells are hematopoietic cells that reside in virtually all vascularized tissues and that
represent potential sources of a wide variety of biologically active secreted products …

Aging is the greatest risk factor for nearly all major chronic diseases, including
cardiovascular diseases, cancer, Alzheimer's and other neurodegenerative diseases of …

Psoriasis is a common inflammatory skin disease with multiple comorbidities, including
psoriatic arthritis and coronary artery disease, that can severely impact an individual's …

Cytokines are small proteins that are secreted by a vast majority of cell types in the gut. They
not only establish cell-to-cell interactions and facilitate cellular signaling, but also regulate …

IL-17-producing T lymphocytes have been recently shown to comprise a distinct lineage of
proinflammatory T helper cells, termed Th17 cells, that are major contributors to autoimmune …

Probiotic bacteria can modulate immune responses in the host gastrointestinal tract to
promote health. The genomics era has provided novel opportunities for the discovery and …

Naive T helper cells differentiate into two subsets, Th1 and Th2, each with distinct functions
and cytokine profiles. Here, we report the isolation of T-bet, a Th1-specific T box transcription …

It is a challenge to effectively reactivate preexisting tumor-infiltrating lymphocytes (TILs)
without causing severe toxicity. Interleukin-12 (IL-12) can potently activate lymphocytes, but …

A novel sequence discovered in a computational screen appears distantly related to the p35
subunit of IL-12. This factor, which we term p19, shows no biological activity by itself; …

The immune system is an organization of cells and molecules with specialized roles in
defending against infection. There are two fundamentally different types of responses to …