Immune checkpoint inhibitors: The linchpins of modern immunotherapy

BA Wilky - Immunological reviews, 2019 - Wiley Online Library
Immune checkpoint inhibitors (ICIs) have revolutionized our approach to cancer treatment in
the past decade. While monoclonal antibodies to CTLA‐4 and PD‐1/PD‐L1 have produced …

Molecular mechanisms underpinning sarcomas and implications for current and future therapy

V Damerell, MS Pepper, S Prince - Signal transduction and targeted …, 2021 - nature.com
Sarcomas are complex mesenchymal neoplasms with a poor prognosis. Their clinical
management is highly challenging due to their heterogeneity and insensitivity to current …

Diagnosis, prognosis, and treatment of alveolar soft-part sarcoma: a review

L Paoluzzi, RG Maki - JAMA oncology, 2019 - jamanetwork.com
Importance Alveolar soft-part sarcoma (ASPS) is a rare, translocation-driven sarcoma of the
soft tissues. Alveolar soft-part sarcoma often affects young adults and is characterized by …

Extraskeletal myxoid chondrosarcoma: state of the art and current research on biology and clinical management

S Stacchiotti, GG Baldi, C Morosi, A Gronchi, R Maestro - Cancers, 2020 - mdpi.com
Simple Summary The aim of this review is to provide an overview of the biological basis of
pathogenesis and current research in extraskeletal myxoid chondrosarcoma (EMC) …

Pazopanib in relapsed osteosarcoma patients: report on 15 cases

A Longhi, A Paioli, E Palmerini, M Cesari… - Acta …, 2019 - Taylor & Francis
Osteosarcoma is a rare bone tumor that occurs in young adults with a subsequent peak in
the fifth decade. Neoadjuvant and adjuvant chemotherapy and surgery cure approximately …

Facts and hopes in immunotherapy of soft-tissue sarcomas

J Martín-Broto, DS Moura, BA Van Tine - Clinical Cancer Research, 2020 - AACR
Sarcomas are mesenchymal tumors, encompassing more than 175 subtypes, each one with
their own genetic complexities. As a result, immunotherapy approaches have not been …

SEOM Clinical Guideline of management of soft-tissue sarcoma (2020)

A de Juan Ferré, R Álvarez Álvarez… - Clinical and …, 2021 - Springer
Soft-tissue sarcomas constitute an uncommon and heterogeneous group of tumors of
mesenchymal origin. Diagnosis, treatment, and management should be performed by an …

Current landscape of immunotherapy for advanced sarcoma

V Albarrán, ML Villamayor, J Pozas, J Chamorro… - Cancers, 2023 - mdpi.com
Simple Summary The systemic treatment of advanced sarcoma remains challenging.
Conventional chemotherapy and anti-angiogenic agents, even in the most responsive …

Immunotherapy for sarcomas

E Nakata, T Fujiwara, T Kunisada, T Ito… - Japanese journal of …, 2021 - academic.oup.com
Sarcomas are a heterogeneous group of malignancies of mesenchymal origin; their
molecular and genomic mechanisms differ with regard to histology. These characteristics …

Emerging Trends in Immunotherapy for Adult Sarcomas

M Husain, L Chen, D Liebner, J Beane… - The …, 2023 - academic.oup.com
Soft-tissue sarcomas (STS) are a rare and heterogeneous group of malignant tumors that
arise from the oncogenic transformation of mesenchymal tissue. There are over 100 distinct …