Thirty years ago, John French wrote a seminal review describing the unique properties of
the arterial intima. 1 His major point was that the smooth muscle cells of the intima have a …

In the current vascular interventional environment, high restenosis rates have increased
awareness of the significance of intimal hyperplasia, a chronic structural lesion that …

Background In the present series of experiments, we examined the onset of cell proliferation
and growth factor expression after balloon overstretch injury to porcine coronary arteries …

To investigate potential interactions between angiotensin II (AII) and the insulin signaling
system in the vasculature, insulin and AII regulation of insulin receptor substrate-1 (IRS-1) …

It is postulated that vascular disease involves a disturbance in the homeostatic balance of
factors regulating vascular tone and structure. Recent developments in gene transfer …

Mineralocorticoids have been suggested to act on blood vessels, leading to increased
vasoreactivity and peripheral resistance. However, the site of their production has so far …

Endothelial dysfunction crucially contributes to the development of impaired coronary and
systemic perfusion as well as reduced exercise capacity in patients with congestive heart …

Background We have demonstrated that accumulated macrophages in human coronary
arteries strongly express angiotensin converting enzyme in accordance with the …

Angiotensin II (Ang II), the effector peptide of the renin–angiotensin system, has been
implied in the pathogenesis of atherosclerosis on various levels. There is abundant …

To develop an effective strategy to prevent neointima formation after angioplasty injury, we
have identified cell-cycle regulatory proteins as targets for inhibition by using antisense …