The intricate balance between microRNA‐induced mRNA decay and translational repression

P Naeli, T Winter, AP Hackett, L Alboushi… - The FEBS …, 2023 - Wiley Online Library
Post‐transcriptional regulation of messenger RNAs (mRNAs)(ie, mechanisms that control
translation, stability and localization) is a critical focal point in spatiotemporal regulation of …

Principles and properties of eukaryotic mRNPs

SF Mitchell, R Parker - Molecular cell, 2014 - cell.com
The proper processing, export, localization, translation, and degradation of mRNAs are
necessary for regulation of gene expression. These processes are controlled by mRNA …

Translational control by changes in poly (A) tail length: recycling mRNAs

L Weill, E Belloc, FA Bava, R Méndez - Nature structural & molecular …, 2012 - nature.com
Beyond the well-known function of poly (A) tail length in mRNA stability, recent years have
witnessed an explosion of information about how changes in tail length and the selection of …

Signs of change? At‐home and breadwinner parents' housework and child‐care time

N Chesley, S Flood - Journal of Marriage and Family, 2017 - Wiley Online Library
Abstract The authors analyze American Time Use Survey data to examine patterns in
domestic work among at‐home and breadwinner parents to gauge how time availability …

The role of disordered protein regions in the assembly of decapping complexes and RNP granules

S Jonas, E Izaurralde - Genes & development, 2013 - genesdev.cshlp.org
The removal of the 5′ cap structure by the decapping enzyme DCP2 inhibits translation
and generally commits the mRNA to irreversible 5′-to-3′ exonucleolytic degradation by …

mRNA poly (A)-tail changes specified by deadenylation broadly reshape translation in Drosophila oocytes and early embryos

SW Eichhorn, AO Subtelny, I Kronja, JC Kwasnieski… - Elife, 2016 - elifesciences.org
Because maturing oocytes and early embryos lack appreciable transcription,
posttranscriptional regulatory processes control their development. To better understand this …

The DDX6–4E-T interaction mediates translational repression and P-body assembly

A Kamenska, C Simpson, C Vindry… - Nucleic acids …, 2016 - academic.oup.com
Abstract 4E-Transporter binds eIF4E via its consensus sequence YXXXXLΦ, shared with
eIF4G, and is a nucleocytoplasmic shuttling protein found enriched in P-(rocessing) bodies …

Translational control by 3′-UTR-binding proteins

E Szostak, F Gebauer - Briefings in functional genomics, 2013 - academic.oup.com
The regulation of mRNA translation is a major checkpoint in the flux of information from the
transcriptome to the proteome. Critical for translational control are the trans-acting factors …

Translational control in cellular and developmental processes

J Kong, P Lasko - Nature Reviews Genetics, 2012 - nature.com
Growing evidence indicates that translational control of specific mRNAs contributes
importantly to genetic regulation across the breadth of cellular and developmental …

Structure and assembly of the NOT module of the human CCR4–NOT complex

A Boland, Y Chen, T Raisch, S Jonas… - Nature structural & …, 2013 - nature.com
The CCR4–NOT deadenylase complex is a master regulator of translation and mRNA
stability. Its NOT module orchestrates recruitment of the catalytic subunits to target mRNAs …