The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …

The target of rapamycin (TOR), discovered 30 years ago, is a highly conserved
serine/threonine protein kinase that plays a central role in regulating cell growth and …

Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

Cells respond to mitochondrial poisons with rapid activation of the adenosine
monophosphate–activated protein kinase (AMPK), causing acute metabolic changes …

Protein phosphorylation, catalyzed by protein kinases (PKs), is one of the most important
post-translational modifications (PTMs), and involved in regulating almost all of biological …

Complex multicellular organisms require a coordinated response from multiple tissues to
maintain whole-body homeostasis in the face of energetic stressors such as fasting, cold …

Insulin-stimulated glucose uptake into muscle and adipose tissue is vital for maintaining
whole-body glucose homeostasis. Insulin promotes glucose uptake into these tissues by …

Understanding the factors that contribute to exercise response variation is the first step in
achieving the goal of developing personalized exercise prescriptions. This review discusses …

Type 2 diabetes is preceded by a defective insulin response, yet our knowledge of the
precise mechanisms is incomplete. Here, we investigate how insulin resistance alters …