Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits

A Caspi, AR Hariri, A Holmes, R Uher… - American journal of …, 2010 - Am Psychiatric Assoc
Evidence of marked variability in response among people exposed to the same
environmental risk implies that individual differences in genetic susceptibility might be at …

Developmental changes in serotonin signaling: Implications for early brain function, behavior and adaptation

S Brummelte, E Mc Glanaghy, A Bonnin, TF Oberlander - Neuroscience, 2017 - Elsevier
Abstract The neurotransmitter serotonin (5-HT) plays a central role in brain development,
regulation of mood, stress reactivity and risk of psychiatric disorders, and thus alterations in …

Long story short: the serotonin transporter in emotion regulation and social cognition

T Canli, KP Lesch - Nature neuroscience, 2007 - nature.com
The gene encoding the serotonin transporter (5-HTT) contains a regulatory variation that has
been associated with anxiety-related traits and susceptibility for depression. Here we …

5-HT1A receptor function in major depressive disorder

J Savitz, I Lucki, WC Drevets - Progress in neurobiology, 2009 - Elsevier
Dysfunction of the serotonin 1A receptor (5-HT1A) may play a role in the genesis of major
depressive disorder (MDD). Here we review the pharmacological, post-mortem, positron …

Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide

J Savitz, WC Drevets - Neuroscience & Biobehavioral Reviews, 2009 - Elsevier
Both major depressive disorder and bipolar disorder are the subject of a voluminous
imaging and genetics literature. Here, we attempt a comprehensive review of MRI and …

Depression and epilepsy: epidemiologic and neurobiologic perspectives that may explain their high comorbid occurrence

AM Kanner, SC Schachter, JJ Barry, DC Hersdorffer… - Epilepsy & Behavior, 2012 - Elsevier
Depression is the most frequent psychiatric comorbidity in people with epilepsy (PWE) with
lifetime prevalence rates ranging between 30 and 35%. Multifactorial variables play a …

Genetics of emotional regulation: the role of the serotonin transporter in neural function

AR Hariri, A Holmes - Trends in cognitive sciences, 2006 - cell.com
Identifying biological mechanisms through which genes lead to individual differences in
emotional behavior is paramount to our understanding of how such differences confer risk …

Neurobiology of addiction: An integrative review

A Goodman - Biochemical pharmacology, 2008 - Elsevier
Evidence that psychoactive substance use disorders, bulimia nervosa, pathological
gambling, and sexual addiction share an underlying biopsychological process is …

Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application

MJ Millan - Pharmacology & therapeutics, 2006 - Elsevier
Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Neurobiology of wisdom: A literature overview

TW Meeks, DV Jeste - Archives of general psychiatry, 2009 - jamanetwork.com
Context Wisdom is a unique psychological trait noted since antiquity, long discussed in
humanities disciplines, recently operationalized by psychology and sociology researchers …