Owing to their ability to efficiently generate ATP required to sustain normal cell function,
mitochondria are often considered the 'powerhouses of the cell'. However, our …

The relationship between metabolism and cell cycle progression is complex and
bidirectional. Cells must rewire metabolism to meet changing biosynthetic demands across …

The capacity of cells to alter bioenergetics in response to the demands of various biological
processes is essential for normal physiology. The coordination of energy sensing and …

The islet in type 2 diabetes (T2D) is characterized by amyloid deposits derived from islet
amyloid polypeptide (IAPP), a protein co-expressed with insulin by β-cells. In common with …

Ovarian cancer is the deadliest gynecological cancer in women, with a survival rate of less
than 30% when the cancer has spread throughout the peritoneal cavity. Aggregation of …

Mitochondria are dynamic organelles constantly undergoing fusion and fission. A concerted
balance between the process of mitochondrial fusion and fission is required to maintain …

The role of the mitochondrial Ca2+ uniporter (MCU) in physiologic cell proliferation remains
to be defined. Here, we demonstrated that the MCU was required to match mitochondrial …

Diabetes, commonly known for its metabolic effects, also critically affects the enteric nervous
system (ENS), which is essential in regulating gastrointestinal (GI) motility, secretion, and …

While critical for neurotransmitter synthesis, 14-3-3 proteins are often assumed to have
redundant functions due to their ubiquitous expression, but despite this assumption, various …

Extracellular microRNAs (miRNAs) are a new class of biomarkers for cellular phenotypes
and disease, and are bioactive signals within intercellular communication networks …