Mendelian randomization: A review of methods for the prevention, assessment, and discussion of pleiotropy in studies using the fat mass and obesity-associated gene …
FIN Mbutiwi, T Dessy, MP Sylvestre - Frontiers in genetics, 2022 - frontiersin.org
Pleiotropy assessment is critical for the validity of Mendelian randomization (MR) analyses,
and its management remains a challenging task for researchers. This review examines how …
and its management remains a challenging task for researchers. This review examines how …
Differences in brain structure and function in children with the FTO obesity‐risk allele
Objective Noncoding alleles of the fat mass and obesity‐associated (FTO) gene have been
associated with obesity risk, yet the underlying mechanisms remain unknown. Risk allele …
associated with obesity risk, yet the underlying mechanisms remain unknown. Risk allele …
Replicative Study in Performance-Related Genes of Brazilian Elite Soccer Players Highlights Genetic Differences from African Ancestry and Similarities between …
T Kanope, CGM Santos, F Marinho, G Monnerat… - Genes, 2023 - mdpi.com
Classically, genetic association studies have attempted to assess genetic polymorphisms
related to human physiology and physical performance. However, the heterogeneity of some …
related to human physiology and physical performance. However, the heterogeneity of some …
Accounting for antihypertensive medication in Mendelian randomization studies of blood pressure: methodological considerations in the Canadian Longitudinal Study …
FIN Mbutiwi, MP Sylvestre - Journal of Hypertension, 2023 - journals.lww.com
Background: Mendelian randomization (MR) studies investigating determinants of blood
pressure (BP) do not account for antihypertensive medication consistently, which may …
pressure (BP) do not account for antihypertensive medication consistently, which may …
Vérification de la pléiotropie en randomisation mendélienne: évaluation méthodologique et application à l'estimation de l'effet causal de l'adiposité sur la pression …
FIN Mbutiwi - 2023 - papyrus.bib.umontreal.ca
Introduction La randomisation mendélienne (RM) est une approche de plus en plus
populaire dans les études observationnelles qui utilise des variants génétiques …
populaire dans les études observationnelles qui utilise des variants génétiques …
The role of m6A modification on mRNA processing in Drosophila melanogaster
T Lenče - 2021 - openscience.ub.uni-mainz.de
Over 170 RNA modifications can decorate various RNA molecules and represent one of the
layers of gene regulation. N6-methyladenosine (m6A) is among the most prevalent …
layers of gene regulation. N6-methyladenosine (m6A) is among the most prevalent …